Results 61 to 70 of about 181,641 (132)

Identification and Optimization of a Truncated Hs‐1‐Derived Antimicrobial Peptide for Enhanced Broad‐Spectrum Antiviral Activity

open access: yesChemMedChem, Volume 21, Issue 13, 14 July 2026.
Can a shorter peptide be a better antiviral? Structure‐guided optimization of the amphibian peptide Hs‐1 reveals a minimal α‐helical core that, after terminal modification, displays enhanced stability and submicromolar broad‐spectrum activity against enveloped viruses while maintaining a favorable safety profile. Antimicrobial peptides (AMPs) represent
Carla Zannella   +10 more
wiley   +1 more source

In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes [PDF]

open access: yes, 2002
A helper-dependent expression system based on transmissible gastroenteritis coronavirus (TGEV) has been developed using a minigenome of 3·9 kb (M39).
Enjuanes, L.   +11 more
core   +1 more source

Table_6_Long-Term Expansion of Porcine Intestinal Organoids Serves as an in vitro Model for Swine Enteric Coronavirus Infection.XLSX

open access: yes, 2022
A reliable and reproducible model in vitro for swine enteric coronaviruses infection would be intestinal models that support virus replication and can be long-term cultured and manipulated experimentally.
Fei Gao (29262)   +11 more
core   +1 more source

Table_1_Long-Term Expansion of Porcine Intestinal Organoids Serves as an in vitro Model for Swine Enteric Coronavirus Infection.DOCX

open access: yes, 2022
A reliable and reproducible model in vitro for swine enteric coronaviruses infection would be intestinal models that support virus replication and can be long-term cultured and manipulated experimentally.
Fei Gao (29262)   +11 more
core   +1 more source

Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus Infections Using Multivalent DNA Nanostructure‐Enabled Lateral Flow Assay

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 26, 10 July 2026.
A multivalent DNA nanostructure‐enabled lateral flow assay was developed for rapid, ultrasensitive detection of porcine epidemic diarrhea virus (PEDV) nucleocapsid protein. Designer net‐shaped DNA nanostructures (DNA‐Net) presenting PEDV‐specific aptamers achieved ~1000‐fold enhanced binding, enabling detection of viral copies with Ct ≤ 37.42 within 10
Saurabh Umrao   +9 more
wiley   +1 more source

Organoids: From Bench to Bedside Applications

open access: yesMedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li   +6 more
wiley   +1 more source

Table_2_Long-Term Expansion of Porcine Intestinal Organoids Serves as an in vitro Model for Swine Enteric Coronavirus Infection.DOCX

open access: yes, 2022
A reliable and reproducible model in vitro for swine enteric coronaviruses infection would be intestinal models that support virus replication and can be long-term cultured and manipulated experimentally.
Fei Gao (29262)   +11 more
core   +1 more source

SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release

open access: yesmLife, Volume 5, Issue 3, Page 339-354, June 2026.
Abstract The mechanism of SARS‐CoV‐2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In this study, using transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like‐particle (SARS‐CoV‐2 trVLP)
Fujun Qin   +7 more
wiley   +1 more source

Table_3_Long-Term Expansion of Porcine Intestinal Organoids Serves as an in vitro Model for Swine Enteric Coronavirus Infection.XLSX

open access: yes, 2022
A reliable and reproducible model in vitro for swine enteric coronaviruses infection would be intestinal models that support virus replication and can be long-term cultured and manipulated experimentally.
Fei Gao (29262)   +11 more
core   +1 more source

Molecular Detection of Alpha‐ and Betacoronaviruses in Bats from Afar Region, Ethiopia

open access: yesVeterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Bats are critical reservoirs of coronaviruses, yet gaps remain in understanding coronavirus diversity within bat populations in Eastern Ethiopia. A total of 141 bats were captured: 129 Chaerephon pumilus, 11 Epomophorus labiatus and 1 Mops condylurus. Coronaviruses detected in eight bats.
Bula Mengesha   +2 more
wiley   +1 more source

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