Efflux Pumps and Porins Enhance Bacterial Tolerance to Phenolic Compounds by Inhibiting Hydroxyl Radical Generation [PDF]
MicroorganismsPhenolic compounds are industrially versatile chemicals that have been successfully produced in microbial cell factories. Unfortunately, most phenolic compounds are highly toxic to cells in specific cellular environments or above a particular ...
Xinyue Sui +4 more
doaj +2 more sources
Interplay between porin deficiency, fitness, and virulence in carbapenem-non-susceptible Pseudomonas aeruginosa and Enterobacteriaceae. [PDF]
PLoS PathogensThe increasing resistance of Gram-negative bacteria to last resort antibiotics, such as carbapenems, is particularly of concern as it is a significant cause of global health threat.
Hedi Mammeri +4 more
doaj +2 more sources
Antibiotic Resistance in Klebsiella pneumoniae and Related Enterobacterales: Molecular Mechanisms, Mobile Elements, and Therapeutic Challenges [PDF]
AntibioticsDrug-resistant Klebsiella pneumoniae and related Enterobacterales represent an escalating global public health threat, increasingly limiting therapeutic options in both healthcare- and community-associated infections.
Veronika Zdarska +3 more
doaj +2 more sources
The ropAe gene encodes a porin‐like protein involved in copper transit in Rhizobium etli CFN42 [PDF]
MicrobiologyOpen, 2018 Copper (Cu) is an essential micronutrient for all aerobic forms of life. Its oxidation states (Cu+/Cu2+) make this metal an important cofactor of enzymes catalyzing redox reactions in essential biological processes.
Antonio González‐Sánchez +4 more
doaj +3 more sources
Understanding Drug Permeability in Pseudomonas aeruginosa [PDF]
LifePseudomonas aeruginosa is a Gram-negative bacterium that poses a serious threat to patients with weakened immunity, cystic fibrosis, severe burns, or those in hospitals.
Ishan Ghai
doaj +2 more sources
Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food [PDF]
Veterinary Sciences, 2018 Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Javier Fernández +2 more
doaj +5 more sources
Quantitative assessment of porin-mediated solute transport in biomimetic membranes [PDF]
Applied Microbiology and BiotechnologyPorins govern nutrient uptake and antibiotic influx in Gram-negative bacteria, making their characterization critical for understanding permeability, resistance mechanisms, and structure-function relationships. From a biotechnological point of view, they
Maike Scherer +5 more
doaj +2 more sources
Outer membrane permeability of Pseudomonas aeruginosa through β-lactams: new evidence on the role of OprD and OpdP porins in antibiotic resistance [PDF]
Microbiology SpectrumGram-negative bacteria are a major concern for public health, particularly due to the continuous rise of antibiotic resistance. A major factor that helps the development of resistance is the outer membrane that is essential since it acts as a strong ...
Francesco Amisano +7 more
doaj +2 more sources
Antibiotics and phages drive region-specific diversity of OmpK36 in Klebsiella pneumoniae [PDF]
mBioThe Enterobacterales outer membrane is impermeable to many antibiotics, but they can enter the cell via channel proteins, called porins. In Klebsiella pneumoniae, the porin OmpK36 is a major determinant of antibiotic resistance.
Guilhem Royer +7 more
doaj +2 more sources
Outer Membrane Porins Contribute to Antimicrobial Resistance in Gram-Negative Bacteria
Microorganisms, 2023 Gram-negative bacteria depend on their cell membranes for survival and environmental adaptation. They contain two membranes, one of which is the outer membrane (OM), which is home to several different outer membrane proteins (Omps).
Gang Zhou +8 more
doaj +1 more source