Efflux Pumps and Porins Enhance Bacterial Tolerance to Phenolic Compounds by Inhibiting Hydroxyl Radical Generation [PDF]
MicroorganismsPhenolic compounds are industrially versatile chemicals that have been successfully produced in microbial cell factories. Unfortunately, most phenolic compounds are highly toxic to cells in specific cellular environments or above a particular ...
Xinyue Sui +4 more
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Interplay between porin deficiency, fitness, and virulence in carbapenem-non-susceptible Pseudomonas aeruginosa and Enterobacteriaceae. [PDF]
PLoS PathogensThe increasing resistance of Gram-negative bacteria to last resort antibiotics, such as carbapenems, is particularly of concern as it is a significant cause of global health threat.
Hedi Mammeri +4 more
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Outer membrane permeability of Pseudomonas aeruginosa through β-lactams: new evidence on the role of OprD and OpdP porins in antibiotic resistance [PDF]
Microbiology SpectrumGram-negative bacteria are a major concern for public health, particularly due to the continuous rise of antibiotic resistance. A major factor that helps the development of resistance is the outer membrane that is essential since it acts as a strong ...
Francesco Amisano +7 more
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Understanding Drug Permeability in Pseudomonas aeruginosa [PDF]
LifePseudomonas aeruginosa is a Gram-negative bacterium that poses a serious threat to patients with weakened immunity, cystic fibrosis, severe burns, or those in hospitals.
Ishan Ghai
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Quantitative assessment of porin-mediated solute transport in biomimetic membranes [PDF]
Applied Microbiology and BiotechnologyPorins govern nutrient uptake and antibiotic influx in Gram-negative bacteria, making their characterization critical for understanding permeability, resistance mechanisms, and structure-function relationships. From a biotechnological point of view, they
Maike Scherer +5 more
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Antibiotics and phages drive region-specific diversity of OmpK36 in Klebsiella pneumoniae [PDF]
mBioThe Enterobacterales outer membrane is impermeable to many antibiotics, but they can enter the cell via channel proteins, called porins. In Klebsiella pneumoniae, the porin OmpK36 is a major determinant of antibiotic resistance.
Guilhem Royer +7 more
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Mechanisms of antimicrobial resistance: From genetic evolution to clinical manifestations [PDF]
AIMS MicrobiologyAntimicrobial resistance (AMR) is a significant global health challenge that threatens the effectiveness of antibiotics and other antimicrobial agents.
Sabiha Nusrat +2 more
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Bacterial Porins and Their Procoagulant Role: Implication in the Pathophysiology of Several Thrombotic Complications during Sepsis [PDF]
ToxinsThe association between sepsis and thrombotic complications is still not well known. Different mechanisms have been shown to be involved in the sepsis-induced prothrombotic state, but clinical scenarios may differ.
Carmine Siniscalchi +9 more
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Outer Membrane Porins Contribute to Antimicrobial Resistance in Gram-Negative Bacteria
Microorganisms, 2023 Gram-negative bacteria depend on their cell membranes for survival and environmental adaptation. They contain two membranes, one of which is the outer membrane (OM), which is home to several different outer membrane proteins (Omps).
Gang Zhou +8 more
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Инфекция и иммунитет, 2022 Introduction. Study of features for interacting antigen-antibody system is of great importance for developing new modern tools for diagnostics and therapy of infectious diseases.
Ilya V. Konyshev +3 more
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