Results 11 to 20 of about 28,026 (256)
Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food [PDF]
Veterinary Sciences, 2018 Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Javier Fernández +2 more
doaj +5 more sources
Porin-Independent Uptake of Small Molecule Antibiotics Facilitated by Escherichia coli Outer Membrane Vesicles. [PDF]
Biotechnol BioengWe demonstrate that bacterial outer membrane vesicles (OMVs) can enhance antibiotic delivery into Gram‐negative bacteria by bypassing porin‐dependent uptake. Encapsulation of imipenem in OMVs significantly increased its effectiveness against multidrug‐resistant clinical isolates, highlighting OMVs as a promising platform for overcoming permeability ...
Wu M, Harrower RM, Li Z, Brown AC.
europepmc +2 more sources
Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. [PDF]
, 2012 Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein.
Bötzel, Kai +5 more
core +15 more sources
A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance
Applied Sciences, 2023 Gram-negative bacteria can resist antibiotics by changing the permeability via their outer membrane. These bacteria have a complex cell envelope that incorporates an outer membrane separating the periplasm from the external environment.
Ishan Ghai
doaj +1 more source
Frontiers in Immunology, 2020 Immunotherapy has improved the clinical response in melanoma patients, although a relevant percentage of patients still cannot be salvaged. The search for the immune populations that provide the best tumor control and that can be coaxed by immunotherapy ...
Ricardo A. León-Letelier +12 more
doaj +1 more source
Roles of the EnvZ/OmpR Two-Component System and Porins in Iron Acquisition in
mBio, 2020 Escherichia coli secretes high-affinity Fe3+ chelators to solubilize and transport chelated Fe3+ via specific outer membrane receptors. In microaerobic and anaerobic growth environments, where the reduced Fe2+ form is predominant, ferrous transport ...
Henri Gerken +3 more
doaj +1 more source
The Influence of Permeability through Bacterial Porins in Whole-Cell Compound Accumulation
Antibiotics, 2021 The lack of new drugs for Gram-negative pathogens is a global threat to modern medicine. The complexity of their cell envelope, with an additional outer membrane, hinders internal accumulation and thus, the access of molecules to their targets.
Silvia Acosta-Gutiérrez +2 more
doaj +1 more source
مجلة مركز بحوث التقنيات الاحيائية, 2010 Approximately, 50% of the dry mass of the outer membrane of gram-negative bacteria consists of proteins, and more than 20 immunochemically distinct proteins (termed outer membrane proteins [OMPs]) have been identified.
Amir H. Al–Shammary +2 more
doaj +3 more sources
Antibiotics, 2021 Meropenem/Vaborbactam (MEM-VAB) is a novel carbapenem- β-lactamase inhibitor active against KPC-producing Enterobacteria. Herein, we evaluate the incidence of meropenem/vaborbactam-resistance among KPC-producing K.
Paolo Gaibani +9 more
doaj +1 more source
The Optimal Permeation of Cyclic Boronates to Cross the Outer Membrane via the Porin Pathway
Antibiotics, 2022 We investigated the diffusion of three cyclic boronates formulated as beta-lactamase inhibitors through the porin OmpF to evaluate their potential to cross OM via the porin pathway.
Gian Marco Tuveri +3 more
doaj +1 more source