Results 71 to 80 of about 24,819 (205)

Cell entry mechanism of enzymatic bacterial colicins: Porin recruitment and the thermodynamics of receptor binding [PDF]

, 2005
Binding of enzymatic E colicins to the vitamin B-12 receptor, BtuB, is the first stage in a cascade of events that culminate in the translocation of the cytotoxic nuclease into the Escherichia coli cytoplasm and release of its tightly bound immunity ...
Housden, Nicholas G., James, Richard, Kleanthous, Colin, Loftus, Steven R., Moore, Geoffrey R.   +4 more
core   +3 more sources

Chromosome‐scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1

Insect Science, EarlyView.
Anastrepha fraterculus sp. 1 is a major fruit fly pest in Argentina, currently controlled through chemical treatments and traps. This study aims to enhance the genomic understanding of this species to support the development of sterile insect technique as well as the use of innovative technologies.
Máximo Rivarola, Claudia A. Conte, Pierre Berube, Shu‐Huang Chen, M. Cecilia Giardini, Alejandra C. Scannapieco, Fabián H. Milla, María C. Soria, Romina M. Russo, Juan P. Wulff, Haig H. Djambazian, Rolando R. Pomar, Alfred M. Handler, Kostas Bourtzis, Ioannis Ragoussis, Silvia B. Lanzavecchia   +15 more
wiley   +1 more source

Teleological cooption of Mycobacterium tuberculosis PE/PPE proteins as porins: Role in molecular immigration and emigration

International Journal of Medical Microbiology, 2021
Permeation through bacterial cells for exchange or uptake of biomolecules and ions invariably depend upon the existence of pore-forming proteins (porins) in their outer membrane. Mycobacterium tuberculosis (M.
Aquib Ehtram, Mohd Shariq, Sabeeha Ali, Neha Quadir, Javaid A. Sheikh, Faraz Ahmad, Tarina Sharma, Nasreen Z. Ehtesham, Seyed E. Hasnain   +8 more
doaj   +1 more source

Membrane proteins and proteomics: Love is possible, but so difficult [PDF]

, 2009
Despite decades of extensive research, the large-scale analysis of membrane proteins remains a difficult task. This is due to the fact that membrane proteins require a carefully balanced hydrophilic and lipophilic environment, which optimum varies with ...
Adessi, Aebersold, Aivaliotis, Aivaliotis, Alla, Ames, Babu, Bagshaw, Bell, Berlanda-Scorza, Berven, Bierczynska-Krzysik, Bisle, Bjellqvist, Bunai, Bunai, Burré, Buxbaum, Casey, Chevallet, Chevallet, Connolly, Coughenour, Cutillas, Devreese, Eravci, Everberg, Felsted, Ferro, Gatlin, Ghosh, Gyenes, Görg, Hagan, Hahne, Hartinger, Helling, Henningsen, Henzel, Hisabori, Hjelmeland, Huang, Huang, James, Jun, Lasonder, Lescuyer, Liberatori, Lopez, Low, Luche, Lyubimova, Lüddens, MacFarlane, MacFarlane, Matsudaira, McDonough, Miguet, Moebius, Molloy, Molloy, Nandakumar, Natera, Navarre, Ong, Papasotiriou, Pappin, Patton, Pedersen, Peng, Perdew, Phadke, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rais, Rubin, Santoni, Santoni, Schindler, Schirle, Schägger, Siroy, Speers, Sweetnam, Switzer, Tastet, Taylor, Towbin, Veith, Washburn, Werner, Wilkins, Williams, Williams, Williams, Wittig, Witzmann, Wu, Yates, Ying, Zahedi   +103 more
core   +5 more sources

The ribosome‐associated complex regulates cytosolic translation upon mitoprotein‐induced stress

The FEBS Journal, EarlyView.
Defects in mitochondrial protein import trigger a stress response. The contribution of translation regulation to such a response is only partially understood. We demonstrate that the deletion of mitochondrial surface proteins (TOM70/TOM71) leads to defects in mitochondrial biogenesis and slow growth.
Jiaxin Qian, Annika Nutz, Katja Hansen, Lea Bertgen, Mirita Franz‐Wachtel, Boris Macek, Johannes M. Herrmann, Doron Rapaport   +7 more
wiley   +1 more source

Fluoroquinolone Metalloantibiotics to Bypass Antimicrobial Resistance Mechanisms: Decreased Permeation through Porins

Membranes, 2020
Fluoroquinolones (FQs) are broad-spectrum antibiotics largely used in the clinical practice against Gram-negative and some Gram-positive bacteria. Nevertheless, bacteria have developed several antimicrobial resistance mechanisms against such class of ...
Mariana Ferreira, Carla F. Sousa, Paula Gameiro   +2 more
doaj   +1 more source

Silver resistance in Gram-negative bacteria: a dissection of endogenous and exogenous mechanisms [PDF]

, 2015
Objectives: To gain a more detailed understanding of endogenous (mutational) and exogenous (horizontally acquired) resistance to silver in Gram-negative pathogens, with an emphasis on clarifying the genetic bases for resistance.
Busse, D, Gupta, A, Jackson, N, O'Neill, AJ, Randall, C   +4 more
core   +2 more sources

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Anti-infectives in Drug Delivery-Overcoming the Gram-Negative Bacterial Cell Envelope. [PDF]

, 2017
Infectious diseases are becoming a major menace to the state of health worldwide, with difficulties in effective treatment especially of nosocomial infections caused by Gram-negative bacteria being increasingly reported.
A Davin-Regli, A Kumar, AI Kuzmenko, AJ Huh, AP Brun Le, C Danelon, C Peetla, C Rodrigues, CW Mullineaux, D Pornpattananangkul, DI Fernandez, DI Fernandez, E De, E Hajjar, E Mataraci, EL Wu, EM Nestorovich, EM Wellington, F Bambeke Van, FC Tenover, G Fragneto, Gerardino D’Errico, H Cai, H Nikaido, H Nikaido, J Kubiak, J Meng, JL Gornall, JM Pages, JM Pages, JM Pages, K Murzyn, K Naghmouchi, KR Mahendran, KR Pandit, L Wang, LA Clifton, LA Clifton, Laura A. Dever, M Kreir, M Luckey, M McKenna, M Murcia-Soler, M Murcia-Soler, M Palusinska-Szysz, MA Fischbach, MB Miller, MH Xiong, MH Xiong, ML Nelson, MT Cronin, N Modi, N Nafee, NA Berglund, NY Yount, O Ries, P Fillion, PR Singh, R O’Shea, RD Lins, RE Hancock, RE Hancock, S Kascakova, S Nuding, SC Park, SP Chakraborty, T Charitat, T Lemmin, T Mach, T Mach, TD Davis, TE Renau, Thomas J. Walsh, TJ Piggot, TJ Silhavy, W Zhao, YJ Gordon   +76 more
core   +2 more sources

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source