Results 61 to 70 of about 1,809,050 (267)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The Wang–Buwang Sequence and Positive Forgetting in Early Confucian Texts
ReligionsThis study investigates the roles of wang (忘, forgetting) and buwang (不忘, non-forgetting) in early Confucian texts, emphasizing their interdependence within a yin–yang framework.
Gad C. Isay
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
ON THE NECESSARY AND SUFFICIENT CONDITIONS FOR THE MEASURABILITY OF A POSITIVE SEQUENCE
Проблемы анализа, 2019 The work is devoted to finding out the necessary and sufficient conditions for the measurability of a sequence of positive numbers. The concept of logarithmic measurability of a sequence is also introduced.
A. F. Kuzhaev
doaj +1 more source
On the Positivity Problem for Simple Linear Recurrence Sequences, [PDF]
, 2014 Given a linear recurrence sequence (LRS) over the integers, the Positivity Problem} asks whether all terms of the sequence are positive. We show that, for simple LRS (those whose characteristic polynomial has no repeated roots) of order 9 or less, Positivity is decidable, with complexity in the Counting Hierarchy.
Joël Ouaknine, James Worrell 0001
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A Family of Fundamental Positive Sequence Detectors Based on Repetitive Schemes
EnergiesIn electrical power systems, the extraction of the fundamental positive sequence (FPS) is paramount for synchronization, power calculation, and a wide variety of metering and control tasks.
Glendy Anyali Catzin-Contreras +3 more
doaj +1 more source
An Analog of Multiplier Sequences for the Set of Totally Positive Sequences
Zurnal matematiceskoj fiziki, analiza, geometriiA real sequence $(b_k)_{k=0}^\infty$ is called totally positive if all minors of the infinite matrix $ \left\| b_{j-i} \right\|_{i, j =0}^\infty$ are nonnegative (here $b_k=0$ for $k<0$). In this paper, we investigate the problem of description of the set of sequences $(a_k)_{k=0}^\infty$ such that for every totally positive sequence $(b_k)_{k=0 ...
Katkova, Olga, Vishnyakova, Anna
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Infinitely divisible positive definite sequences [PDF]
Transactions of the American Mathematical Society, 1969 Introduction. Sequences of complex numbers which generate positive semidefinite Toeplitz or Hankel matrices occur naturally in many areas of mathematics and are usually called positive definite sequences. It is well known that a sequence formed from a positive integer power of the terms of a positive definite sequence is always itself a positive ...
openaire +2 more sources