Results 11 to 20 of about 218,924 (216)

Regulation of PD-L1 expression in the tumor microenvironment

Journal of Hematology & Oncology, 2021
Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple cancer types, the PD-1/PD-L1 axis is the major speed-limiting step of the anti-cancer immune
Ming Yi, Mengke Niu, Linping Xu, Suxia Luo, Kongming Wu   +4 more
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Biosynthesis and functions of sulfur modifications in tRNA

Frontiers in Genetics, 2014
Sulfur is an essential element for a variety of cellular constituents in all living organisms. In tRNA molecules, there are many sulfur-containing nucleosides, such as the derivatives of 2‑thiouridine (s2U), 4-thiouridine (s4U), 2-thiocytidine (s2C), and
Naoki eShigi
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Phospho.ELM: A database of experimentally verified phosphorylation sites in eukaryotic proteins

BMC Bioinformatics, 2004
Background Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes. The fast growing number of research reports on
Via Allegra, Linding Rune, Gemünd Christine, Cameron Scott, Diella Francesca, Kuster Bernhard, Sicheritz-Pontén Thomas, Blom Nikolaj, Gibson Toby J   +8 more
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Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

Molecular Cancer, 2021
Background The four major RNA adenosine modifications, i.e., m6A, m1A, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” enzymes and constitute critical mechanisms of epigenetic regulation in immune ...
Huifang Chen, Jiameng Yao, Rujuan Bao, Yu Dong, Ting Zhang, Yanhua Du, Gaoyang Wang, Duan Ni, Zhenzhen Xun, Xiaoyin Niu, Youqiong Ye, Hua-Bing Li   +11 more
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Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements

Cell Reports, 2016
MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it challenging to delineate miRNA-mediated effects.
Sara J.C. Gosline, Allan M. Gurtan, Courtney K. JnBaptiste, Andrew Bosson, Pamela Milani, Simona Dalin, Bryan J. Matthews, Yoon S. Yap, Phillip A. Sharp, Ernest Fraenkel   +9 more
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The Role of LncRNAs in Translation

Non-Coding RNA, 2021
Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional ...
Didem Karakas, Bulent Ozpolat
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The role of cullin4B in human cancers

Experimental Hematology & Oncology, 2017
Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases.
Ying Li, Xin Wang
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Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo

Nature Communications, 2021
Post transcriptional modification of RNAs represents an important layer of gene regulation. Here the authors describe NAIL-MS—a method for monoisotopic RNA labeling in cell culture—demonstrating its capabilities by analyzing the modification kinetics of ...
Matthias Heiss, Felix Hagelskamp, Virginie Marchand, Yuri Motorin, Stefanie Kellner   +4 more
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Transcriptome-wide analysis of pseudouridylation in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2022
Pseudouridine (Psi) is one of the most frequent post-transcriptional modification of RNA. Enzymatic Psi modification occurs on rRNA, snRNA, snoRNA, tRNA, and non-coding RNA and has recently been discovered on mRNA.
Wan Song, Ram Podicheti, Douglas B Rusch, William Daniel Tracey   +3 more
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Novel insights into the multifaceted roles of m6A-modified LncRNAs in cancers: biological functions and therapeutic applications

Biomarker Research, 2023
N6-methyladenosine (m6A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer.
Jinxin Tang, Jinhui Zhang, Yu Lu, Jieyu He, Hua Wang, Binfeng Liu, Chao Tu, Zhihong Li   +7 more
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