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The diversity of post-transcriptional gene silencing mediated by small silencing RNAs in plants
Essays in Biochemistry, 2020Abstract In plants, post-transcriptional gene silencing (PTGS) tightly regulates development, maintains genome stability and protects plant against foreign genes. PTGS can be triggered by virus infection, transgene, and endogenous transcript, thus commonly serves as an RNA-based immune mechanism.
Huijuan Tan, Bosheng Li, Hongwei Guo
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Spreading of post‐transcriptional gene silencing along the target gene promotes systemic silencing
The Plant Journal, 2004SummaryTransitive silencing and grafting‐induced gene silencing phenomena were combined to investigate whether a primary target β‐glucuronidase (gus) gene could promote the generation of systemic transitive silencing signals. Tobacco plants with hemizygous or homozygous silencer locus and in trans silenced primary target were used as a source of post ...
Rubén Darío, García-Pérez +2 more
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2022
Loss-of-function analyses are essential to dissect the complex nature of biological processes, including gametogenesis. Virus-induced gene silencing (VIGS) has been widely used in crop species as an amenable and rapid way to generate gene knockdowns. As a transient assay, VIGS circumvents the generation of stable transgenic lines through laborious and ...
Wang, Zhengming +3 more
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Loss-of-function analyses are essential to dissect the complex nature of biological processes, including gametogenesis. Virus-induced gene silencing (VIGS) has been widely used in crop species as an amenable and rapid way to generate gene knockdowns. As a transient assay, VIGS circumvents the generation of stable transgenic lines through laborious and ...
Wang, Zhengming +3 more
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Post-transcriptional gene silencing: conservation and sequences
Trends in Plant Science, 2000Gene expression is controlled by a variety of mechanisms. Post-transcriptional gene silencing (PTGS) is one mechanism that degrades specific messenger RNAs and thereby reduces the expression of a specific gene. PTGS has many names: cosuppression in plants, quelling in fungi and RNA interference in animals, but in all cases, degraded mRNA decreases gene
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The Design and Exogenous Delivery of siRNA for Post-transcriptional Gene Silencing
Journal of Drug Targeting, 2004RNA interference (RNAi) is a natural cellular process that effects post-transcriptional gene silencing in eukaryotic systems. Small interfering RNA (siRNA) molecules are the key intermediaries in this process which when exogenously administered can inhibit or "silence" the expression of any given target gene. Thus, siRNA molecules hold great promise as
Ian R, Gilmore +4 more
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RNA degradation and models for post-transcriptional gene silencing
Plant Molecular Biology, 2000Post-transcriptional gene silencing (PTGS) is a form of stable but potentially reversible epigenetic modification, which frequently occurs in transgenic plants. The interaction in trans of genes with similar transcribed sequences results in sequence-specific degradation of RNAs derived from the genes involved.
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Post-transcriptional Gene Silencing and Translation in Giardia
2011The control of gene expression in Giardia lamblia includes several mechanisms already described in higher eukaryotes, but with some interesting features for this early-branching organism. Here we describe two gene expression control systems in Giardia, posttranscriptional gene silencing (PTGS) and translation, and the close interaction between them ...
Gargantini, Pablo Ruben +2 more
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RNA viruses as inducers, suppressors and targets of post-transcriptional gene silencing
Plant Molecular Biology, 2000Post-transcriptional gene silencing (PTGS) is a fundamental regulatory mechanism operating in diverse types of organisms, but the cellular components of the gene silencing machinery and the regulation of the process are not understood. Recent findings that cytoplasmically replicating RNA viruses act as both targets and inducers of PTGS has led to the ...
R, Marathe +4 more
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Conservation of transgene-induced post-transcriptional gene silencing in plants and fungi
Trends in Plant Science, 1997Different types of post-transcriptional transgene-induced gene silencing have been shown to occur in Neurospora (quelling) and plants (co-suppression). Common mechanistic features include triggering by duplicated coding sequences, simultaneous silencing of the transgene and endogenous genes, reversibility of silencing and post-transcriptional ...
COGONI, Carlo, MACINO, Giuseppe
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Role of inverted DNA repeats in transcriptional and post-transcriptional gene silencing
Plant Molecular Biology, 2000Transgenes and endogenous genes are sensitive to silencing, in particular when the genes are tandemly repeated. Their expression can be transcriptionally or post-transcriptionally repressed, or both. It is remarkable that very often, two or more genes or parts of the genes are arranged as inverted repeats (IR).
Muskens, M. +3 more
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