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Post-transcriptional gene silencing across kingdoms
Current Opinion in Genetics and Development, 2000 Post-transcriptional gene silencing (PTGS) as a consequence of the introduction of either transgenes or double-stranded RNA molecules has been found to occur in a number of species. In the past year, studies in different systems have greatly enhanced our understanding of the molecular mechanisms of these phenomena.
Carlo Cogoni, Giuseppe Macino
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Post-transcriptional gene silencing in plants by RNA
Plant Cell Reports, 2003RNA silencing, which is termed post-transcriptional gene silencing in plants, is an RNA degradation process through sequence-specific nucleotide interactions induced by double-stranded RNA. In plants, RNA silencing not only serves as a component of the defense mechanism, but also participates in the regulation of endogenous gene expression in a variety
Prakash P Kumar
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Post-transcriptional gene silencing: Basic concepts and applications
Journal of Biosciences, 2020 Post-transcriptional gene silencing (PTGS)-mediated gene silencing exploits the cellular mechanism wherein transcripts having sequence similarity to the double-stranded RNA (dsRNA) molecules present in the cell will be subjected to degradation. PTGS is closely related to natural processes such as RNA-mediated virus resistance and cross-protection in ...
M Sujatha, V Dinesh Kumar
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Post-transcriptional gene silencing mutants
Plant Molecular Biology, 2000It has been known for more than a decade that increasing the gene copy number does not necessarily lead to increased gene activity. Plants have developed efficient mechanisms such as post-transcriptional gene silencing (PTGS) to regulate abnormal gene expression in a sequence-specific fashion.
Morel, J.B., Vaucheret, Herve
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Post-transcriptional gene silencing activity of human GIGYF2
Biochemical and Biophysical Research Communications, 2016In mammalian post-transcriptional gene silencing, the Argonaute protein AGO2 indirectly recruits translation inhibitors, deadenylase complexes, and decapping factors to microRNA-targeted mRNAs, thereby repressing mRNA translation and accelerating mRNA decay.
Marie-Hélène Kryszke
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Post-transcriptional gene silencing in neurons
Current Opinion in Neurobiology, 2004The techniques evolving from the rapidly developing field of small RNAs promise accessible approaches to dissecting cellular and molecular mechanisms of higher brain function. Here, a current overview of the technology is presented, along with an outline of how these approaches might help neuroscientists to more rapidly uncover the cellular and ...
Henry C, Zeringue +1 more
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Post-transcriptional gene silencing in plants
Journal of Cell Science, 2001Post-transcriptional gene silencing (PTGS) in plants is an RNA-degradation mechanism that shows similarities to RNA interference (RNAi) in animals. Indeed, both involve double-stranded RNA (dsRNA), spread within the organism from a localised initiating area, correlate with the accumulation of small interfering RNA (siRNA) and require putative RNA ...
Vaucheret, Herve +2 more
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Post-transcriptional gene silencing by siRNAs and miRNAs
Current Opinion in Structural Biology, 2005Recent years have seen a rapid increase in our understanding of how double-stranded RNA (dsRNA) and 21- to 25-nucleotide small RNAs, microRNAs (miRNAs) and small interfering RNAs (siRNAs), control gene expression in eukaryotes. This RNA-mediated regulation generally results in sequence-specific inhibition of gene expression; this can occur at levels as
Filipowicz W +3 more
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Post-transcriptional gene silencing in plants: a double-edged sword [PDF]
Science China Life Sciences, 2015 في النباتات، يحمي إسكات الجينات بعد النسخ (PTGS) الجينوم من الجينات الغريبة ويقيد التعبير عن بعض الجينات الداخلية من أجل النمو السليم. هنا، نستعرض التقدم الأخير حول كيفية تجنب PTGS غير المرغوب فيه في النباتات. كخطوة من خطوات صنع القرار في اختبار PTGS، يتم فرز النصوص الشاذة من معظم جينات الترميز الداخلية بدقة إلى مسارات اضمحلال الحمض النووي الريبي ثنائي
Hongwei Guo, Xinyan Zhang
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Post-transcriptional gene silencing by double-stranded RNA
Nature Reviews Genetics, 2001Imagine being able to knock out your favourite gene with only a day's work. Not just in one model system, but in virtually any organism: plants, flies, mice or cultured cells. This sort of experimental dream might one day become reality as we learn to harness the power of RNA interference, the process by which double-stranded RNA induces the silencing ...
S M, Hammond, A A, Caudy, G J, Hannon
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