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Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells. [PDF]
STAR ProtocAdami A +4 more
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Targeting epigenetic remodeling of the blood-brain barrier: current knowledge for drug therapy. [PDF]
EpigenomicsAkhoury M +4 more
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Post-transcriptional gene silencing in plants
Current Opinion in Cell Biology, 1997Overexpression of chimeric transgenes in plants can trigger post-transcriptional gene silencing that is dependent on epigenetic information and physiological conditions. The current view is that unproductive RNA serves as a crucial signal for gene silencing, although direct evidence is lacking for this theory.
Ann Depicker, Marc Van Montagu
exaly +3 more sources
Post-transcriptional gene silencing by double-stranded RNA
Nature Reviews Genetics, 2001Imagine being able to knock out your favourite gene with only a day's work. Not just in one model system, but in virtually any organism: plants, flies, mice or cultured cells. This sort of experimental dream might one day become reality as we learn to harness the power of RNA interference, the process by which double-stranded RNA induces the silencing ...
Amy A Caudy
exaly +3 more sources
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
Nature, 2000In a diverse group of organisms that includes Caenorhabditis elegans, Drosophila, planaria, hydra, trypanosomes, fungi and plants, the introduction of double-stranded RNAs inhibits gene expression in a sequence-specific manner. These responses, called RNA interference or post-transcriptional gene silencing, may provide anti-viral defence, modulate ...
Emily Bernstein
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Post-transcriptional gene silencing mutants
Plant Molecular Biology, 2000It has been known for more than a decade that increasing the gene copy number does not necessarily lead to increased gene activity. Plants have developed efficient mechanisms such as post-transcriptional gene silencing (PTGS) to regulate abnormal gene expression in a sequence-specific fashion.
Morel, J.B., Vaucheret, Herve
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Post-transcriptional gene silencing across kingdoms
Current Opinion in Genetics & Development, 2000Post-transcriptional gene silencing (PTGS) as a consequence of the introduction of either transgenes or double-stranded RNA molecules has been found to occur in a number of species. In the past year, studies in different systems have greatly enhanced our understanding of the molecular mechanisms of these phenomena.
COGONI, Carlo, MACINO, Giuseppe
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Post-transcriptional gene silencing in neurons
Current Opinion in Neurobiology, 2004The techniques evolving from the rapidly developing field of small RNAs promise accessible approaches to dissecting cellular and molecular mechanisms of higher brain function. Here, a current overview of the technology is presented, along with an outline of how these approaches might help neuroscientists to more rapidly uncover the cellular and ...
Henry C, Zeringue +1 more
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Post-transcriptional gene silencing in plants
Journal of Cell Science, 2001Post-transcriptional gene silencing (PTGS) in plants is an RNA-degradation mechanism that shows similarities to RNA interference (RNAi) in animals. Indeed, both involve double-stranded RNA (dsRNA), spread within the organism from a localised initiating area, correlate with the accumulation of small interfering RNA (siRNA) and require putative RNA ...
Vaucheret, Herve +2 more
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Post-transcriptional gene silencing in plants by RNA
Plant Cell Reports, 2003RNA silencing, which is termed post-transcriptional gene silencing in plants, is an RNA degradation process through sequence-specific nucleotide interactions induced by double-stranded RNA. In plants, RNA silencing not only serves as a component of the defense mechanism, but also participates in the regulation of endogenous gene expression in a variety
H, Yu, P P, Kumar
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