Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in Neurodegeneration. [PDF]
BiomoleculesNeurodegenerative disorders, such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease, are identified and characterized by the progressive loss of neurons and neuronal dysfunction, resulting in cognitive and motor impairment.
Zafar S, Fatima SI, Schmitz M, Zerr I.
europepmc +9 more sources
Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats. [PDF]
J Proteome Res, 2017 Post-translational modifications (PTMs) of proteins regulate various cellular processes. PTMs of polyglutamine-expanded huntingtin (Htt) protein, which causes Huntington's disease (HD), are likely modulators of HD pathogenesis. Previous studies have identified and characterized several PTMs on exogenously expressed Htt fragments, but none of them were ...
Ratovitski T +15 more
europepmc +7 more sources
Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States [PDF]
Journal of the American Chemical Society, 2018 The microtubule-associated protein Tau plays a central role in neurodegeneration and is a leading therapeutic target for the treatment of Alzheimer's disease (AD). Several lines of evidence suggest that post-translational modifications (PTMs) regulate the function(s) of Tau, including its subcellular localization, clearance, aggregation, toxicity, and ...
Mahmood Haj-Yahya, Hilal A Lashuel
exaly +6 more sources
Post-translational Modifications (PTMs), from a Cancer Perspective: An Overview
Oncogen, 2019 Studies on post-translational modifications (PTMs) have grabbed attention of the scientific community worldwide, its role in pathogenesis of cancer and prognostic biomarkers associated with cancers.
B. Sharan Sharma +5 more
semanticscholar +4 more sources
Functional Regulation of Hsp70 Allostery by Post‐Translational Modifications (PTMs)
The FASEB Journal, 2020 The 70‐kDa heat shock proteins (Hsp70s) perform critical functions in the protein homeostasis network, such as assisting nascent chain folding, preventing protein misfolding and aggregation, facilitating assembly of complexes, and driving protein translocation.
Wenli Meng +2 more
semanticscholar +4 more sources
Mass spectrometry analysis of transthyretin (TTR) post-translational modifications (PTMs) in hereditary ATTR: a case-control Spanish experience [PDF]
Orphanet J Rare Dis, 2015 Background Transthyretin (TTR) is an amyloidogenic tetrameric protein, present in human plasma, associated with several familial amyloidoses. Variability of TTR is not only due to point mutations in the encoding gene but also to post-translational modifications (PTMs) at Cys10, being the most common PTMs the S-sulfonation, S-glycinylcysteinylation, S ...
Vilà-Rico M +7 more
europepmc +6 more sources
Post-translational modifications and their implications in cancer
Frontiers in Oncology, 2023 Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as
Hashnu Dutta +3 more
doaj +2 more sources
Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila. [PDF]
NPJ AgingSkeletal muscle weakness is a major component of age-associated frailty, but the underlying mechanisms are not completely understood. Drosophila has emerged as a useful model for studying skeletal muscle aging. In this organism, previous lab-based selection established strains with increased longevity and reduced age-associated muscle functional ...
Poudel S +3 more
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Frontiers in Neurology, 2021 Post-translational modifications (PTMs) on tau have long been recognized as affecting protein function and contributing to neurodegeneration. The explosion of information on potential and observed PTMs on tau provides an opportunity to better understand ...
Carolina Alquezar +2 more
doaj +2 more sources
Control of protein stability by post-translational modifications
Nature Communications, 2023 Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation.
Ji Min Lee +3 more
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