Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation. [PDF]
Mol Cell Proteomics, 2016 Histones are abundant chromatin constituents carrying numerous post-translational modifications (PTMs). Such PTMs mediate a variety of biological functions, including recruitment of enzymatic readers, writers and erasers that modulate DNA replication, transcription and repair. Individual histone molecules contain multiple coexisting PTMs, some of which
Schwämmle V +6 more
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Adaptable Alchemy: Exploring the Flexibility of Specialized Metabolites to Environmental Perturbations Through Post-Translational Modifications (PTMs). [PDF]
Plants (Basel)Plants are subjected to various stresses during the growth process, including biotic stresses, as well as abiotic stresses such as temperature, drought, salt, and heavy metals. To cope with these biotic and abiotic adversities, plants have evolved complex regulatory mechanisms during their long-term environmental adaptations.
Cimmino L +5 more
europepmc +4 more sources
Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats. [PDF]
J Proteome Res, 2017 Post-translational modifications (PTMs) of proteins regulate various cellular processes. PTMs of polyglutamine-expanded huntingtin (Htt) protein, which causes Huntington's disease (HD), are likely modulators of HD pathogenesis. Previous studies have identified and characterized several PTMs on exogenously expressed Htt fragments, but none of them were ...
Ratovitski T +15 more
europepmc +6 more sources
Mass spectrometry analysis of transthyretin (TTR) post-translational modifications (PTMs) in hereditary ATTR: a case-control Spanish experience [PDF]
Orphanet J Rare Dis, 2015 Background Transthyretin (TTR) is an amyloidogenic tetrameric protein, present in human plasma, associated with several familial amyloidoses. Variability of TTR is not only due to point mutations in the encoding gene but also to post-translational modifications (PTMs) at Cys10, being the most common PTMs the S-sulfonation, S-glycinylcysteinylation, S ...
Vilà-Rico M +7 more
europepmc +6 more sources
Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in Neurodegeneration. [PDF]
BiomoleculesNeurodegenerative disorders, such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease, are identified and characterized by the progressive loss of neurons and neuronal dysfunction, resulting in cognitive and motor impairment.
Zafar S, Fatima SI, Schmitz M, Zerr I.
europepmc +8 more sources
Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila. [PDF]
NPJ AgingSkeletal muscle weakness is a major component of age-associated frailty, but the underlying mechanisms are not completely understood. Drosophila has emerged as a useful model for studying skeletal muscle aging. In this organism, previous lab-based selection established strains with increased longevity and reduced age-associated muscle functional ...
Poudel S +3 more
europepmc +3 more sources
The Burden of Post-Translational Modification (PTM)—Disrupting Mutations in the Tumor Matrisome [PDF]
Cancers, 2021 Background: To evaluate the occurrence of mutations affecting post-translational modification (PTM) sites in matrisome genes across different tumor types, in light of their genomic and functional contexts and in comparison with the rest of the genome.
Elisa Holstein +7 more
+11 more sources
Protein PTMs: post‐translational modifications or pesky trouble makers? [PDF]
Journal of Mass Spectrometry, 2010 AbstractAnalysis of protein post‐translational modifications using mass spectrometry is an intensive area of proteomic research. This perspective discusses the current state of the field with respect to what can be achieved, the challenges encountered, most notably with modification site assignment, the reliability of the published results ...
Ralph Bradshaw +2 more
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PTM-Shepherd: Analysis and Summarization of Post-Translational and Chemical Modifications From Open Search Results [PDF]
Molecular & Cellular Proteomics, 2020 ABSTRACTOpen searching has proven to be an effective strategy for identifying both known and unknown modifications in shotgun proteomics experiments. Rather than being limited to a small set of user-specified modifications, open searches identify peptides with any mass shift that may correspond to a single modification or a combination of several ...
Daniel Geiszler +5 more
+10 more sources
Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology—part I [PDF]
Amino Acids, 2021 Dimitrios Tsikas
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