The Burden of Post-Translational Modification (PTM)—Disrupting Mutations in the Tumor Matrisome [PDF]
Cancers, 2021 Background: To evaluate the occurrence of mutations affecting post-translational modification (PTM) sites in matrisome genes across different tumor types, in light of their genomic and functional contexts and in comparison with the rest of the genome.
Elisa Holstein +7 more
+11 more sources
Protein PTMs: post‐translational modifications or pesky trouble makers? [PDF]
Journal of Mass Spectrometry, 2010 AbstractAnalysis of protein post‐translational modifications using mass spectrometry is an intensive area of proteomic research. This perspective discusses the current state of the field with respect to what can be achieved, the challenges encountered, most notably with modification site assignment, the reliability of the published results ...
Ralph Bradshaw +2 more
openalex +5 more sources
PTM-Shepherd: Analysis and Summarization of Post-Translational and Chemical Modifications From Open Search Results [PDF]
Molecular & Cellular Proteomics, 2020 ABSTRACTOpen searching has proven to be an effective strategy for identifying both known and unknown modifications in shotgun proteomics experiments. Rather than being limited to a small set of user-specified modifications, open searches identify peptides with any mass shift that may correspond to a single modification or a combination of several ...
Daniel Geiszler +5 more
+9 more sources
Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology—part I [PDF]
Amino Acids, 2021 Dimitrios Tsikas
openalex +3 more sources
Post-Translational Modification (PTM) Proteomics: Challenges and Perspectives [PDF]
Modern Chemistry & Applications, 2013 Copyright: © 2013 Darie CC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Costel C. Darie
openalex +3 more sources
The logic of protein post‐translational modifications (PTMs): Chemistry, mechanisms and evolution of protein regulation through covalent attachments [PDF]
BioessaysProtein post‐translational modifications (PTMs) play a crucial role in all cellular functions by regulating protein activity, interactions and half‐life.
Marcin J. Suskiewicz
openalex +2 more sources
Unconventional protein post-translational modifications: the helmsmen in breast cancer
Cell & Bioscience, 2022 Breast cancer is the most prevalent malignant tumor and a leading cause of mortality among females worldwide. The tumorigenesis and progression of breast cancer involve complex pathophysiological processes, which may be mediated by post-translational ...
Jiena Liu +4 more
doaj +2 more sources
Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis [PDF]
Cells, 2019 Liver fibrosis is characterized by the excessive deposition of extracellular matrix proteins including collagen that occurs in most types of chronic liver disease. Even though our knowledge of the cellular and molecular mechanisms of liver fibrosis has deeply improved in the last years, therapeutic approaches for liver fibrosis remain limited ...
Sofía Lachiondo‐Ortega +7 more
+8 more sources
Proteomic Analysis of Histone Variants and Their PTMs: Strategies and Pitfalls
Proteomes, 2018 Epigenetic modifications contribute to the determination of cell fate and differentiation. The molecular mechanisms underlying histone variants and post-translational modifications (PTMs) have been studied in the contexts of development, differentiation,
Sara El Kennani +2 more
exaly +3 more sources
Nature Communications, 2022 Post-translational modifications (PTMs) can regulate cellular protein function but their global impact on protein turnover is largely unknown. Here, the authors develop proteomic workflows to profile PTM-resolved protein turnover and analyze the effects ...
Jana Zecha +7 more
doaj +2 more sources