Novel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications (PTMs) in Skeletal Muscles Identified by Top-down Proteomics. [PDF]
Mol Cell Proteomics, 2018 Wei L +10 more
europepmc +3 more sources
Post-Translational Modification (PTM) Proteomics: Challenges and Perspectives [PDF]
Modern Chemistry & Applications, 2013 Copyright: © 2013 Darie CC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Costel C. Darie
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Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis [PDF]
Cells, 2019 Liver fibrosis is characterized by the excessive deposition of extracellular matrix proteins including collagen that occurs in most types of chronic liver disease. Even though our knowledge of the cellular and molecular mechanisms of liver fibrosis has deeply improved in the last years, therapeutic approaches for liver fibrosis remain limited ...
Sofía Lachiondo‐Ortega +7 more
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Functions and mechanisms of non-histone post-translational modifications in cancer progression [PDF]
Cell Death DiscoveryProtein post-translational modifications (PTMs) refer to covalent and enzymatic alterations to folded or nascent proteins during or after protein biosynthesis to alter the properties and functions of proteins.
Zongyang Li +6 more
doaj +2 more sources
Networking of predicted post-translational modification (PTM) sites in human EGFR [PDF]
Bioinformation, 2019 Epidermal growth factor receptor (EGFR) binds to EGF activating tyrosine phosphorylation through receptor dimerization prompting uncontrolled multiplication. Domain organization, secondary structure combinations in motifs and interactome define such transitory changes responsible for the multi-functionality of human EGFR.
A.U. Malik +3 more
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STRAP PTM: Software Tool for Rapid Annotation and Differential Comparison of Protein Post‐Translational Modifications [PDF]
Current Protocols in Bioinformatics, 2013 AbstractThe identification of protein post‐translational modifications (PTMs) is an increasingly important component of proteomics and biomarker discovery, but very few tools exist for performing fast and easy characterization of global PTM changes and differential comparison of PTMs across groups of data obtained from liquid chromatography–tandem mass
J. L. Spencer +4 more
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PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications [PDF]
Cell Biochemistry and Biophysics, 2011 Deubiquitinating enzymes (DUBs) constitute a diverse protein family and their impact on numerous biological and pathological processes has now been widely appreciated. Many DUB functions have to be tightly controlled within the cell, and this can be achieved in several ways, such as substrate-induced conformational changes, binding to adaptor proteins,
Benedikt M. Kessler, Mariola J. Edelmann
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Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications [PDF]
Nucleic Acids Research, 2013 Post-translational modifications (PTMs) play a key role in numerous cellular processes by directly affecting structure, dynamics and interaction networks of target proteins. Despite their importance, our understanding of protein PTMs at the atomistic level is still largely incomplete.
Christian Margreitter +2 more
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Functional Regulation of Hsp70 Allostery by Post‐Translational Modifications (PTMs)
The FASEB Journal, 2020 The 70‐kDa heat shock proteins (Hsp70s) perform critical functions in the protein homeostasis network, such as assisting nascent chain folding, preventing protein misfolding and aggregation, facilitating assembly of complexes, and driving protein translocation.
Wenli Meng +2 more
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Post-translational Modifications (PTMs), from a Cancer Perspective: An Overview
Oncogen, 2019 B. Sharan Sharma +5 more
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