STRAP PTM: Software Tool for Rapid Annotation and Differential Comparison of Protein Post‐Translational Modifications [PDF]
Current Protocols in Bioinformatics, 2013 AbstractThe identification of protein post‐translational modifications (PTMs) is an increasingly important component of proteomics and biomarker discovery, but very few tools exist for performing fast and easy characterization of global PTM changes and differential comparison of PTMs across groups of data obtained from liquid chromatography–tandem mass
J. L. Spencer +4 more
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Networking of predicted post-translational modification (PTM) sites in human EGFR [PDF]
Bioinformation, 2019 Epidermal growth factor receptor (EGFR) binds to EGF activating tyrosine phosphorylation through receptor dimerization prompting uncontrolled multiplication. Domain organization, secondary structure combinations in motifs and interactome define such transitory changes responsible for the multi-functionality of human EGFR.
A.U. Malik +3 more
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PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications [PDF]
Cell Biochemistry and Biophysics, 2011 Deubiquitinating enzymes (DUBs) constitute a diverse protein family and their impact on numerous biological and pathological processes has now been widely appreciated. Many DUB functions have to be tightly controlled within the cell, and this can be achieved in several ways, such as substrate-induced conformational changes, binding to adaptor proteins,
Benedikt M. Kessler, Mariola J. Edelmann
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Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications [PDF]
Nucleic Acids Research, 2013 Post-translational modifications (PTMs) play a key role in numerous cellular processes by directly affecting structure, dynamics and interaction networks of target proteins. Despite their importance, our understanding of protein PTMs at the atomistic level is still largely incomplete.
Christian Margreitter +2 more
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Redox Biology, 2021 Thiol-based post-translational modifications (PTMs) play a key role in redox-dependent regulation and signaling. Functional cysteine (Cys) sites serve as redox switches, regulated through multiple types of PTMs.
Xiaolu Li +10 more
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Special Issue “Structure, Activity, and Function of Protein Methyltransferases”
Life, 2022 Post-translational modifications (PTMs) largely expand the functional diversity of the proteome [...]
Arunkumar Dhayalan, Albert Jeltsch
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Cas9 Protein Post-translational Modifications (PTMs): A Potential Biomarker of Gene-editing
, 2019 Joshua D. Podlevsky
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PTMViz: a tool for analyzing and visualizing histone post translational modification data
BMC Bioinformatics, 2021 Background Histone post-translational modifications (PTMs) play an important role in our system by regulating the structure of chromatin and therefore contribute to the regulation of gene and protein expression. Irregularities in histone PTMs can lead to
Kevin Chappell +6 more
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Human Proteomic Variation Revealed by Combining RNA-Seq Proteogenomics and Global Post-Translational Modification (G-PTM) Search Strategy [PDF]
Journal of Proteome Research, 2015 Mass-spectrometry-based proteomic analysis underestimates proteomic variation due to the absence of variant peptides and posttranslational modifications (PTMs) from standard protein databases. Each individual carries thousands of missense mutations that lead to single amino acid variants, but these are missed because they are absent from generic ...
Anthony J. Cesnik +4 more
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RECENT ADVANCES IN POST-TRANSLATIONAL REGULATION OF PLANT DEFENSE RESPONSES BEYOND PHOSPHORYLATION [PDF]
Journal of Plant Development, 2021 During plant-microbe interactions, plant immune signaling relies significantly on post-translational modifications (PTMs) to induce rapid downstream changes.
Tim XING, Ziwei GUO
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