Thirty years of molecular dynamics simulations on posttranslational modifications of proteins [PDF]
, 2022 Posttranslational modifications (PTMs) are an integral component to how cells respond to perturbation. While experimental advances have enabled improved PTM identification capabilities, the same throughput for characterizing how structural changes caused by PTMs equate to altered physiological function has not been maintained.
arxiv +1 more source
The logic of protein post‐translational modifications (PTMs): Chemistry, mechanisms and evolution of protein regulation through covalent attachments [PDF]
BioEssaysAbstractProtein post‐translational modifications (PTMs) play a crucial role in all cellular functions by regulating protein activity, interactions and half‐life. Despite the enormous diversity of modifications, various PTM systems show parallels in their chemical and catalytic underpinnings. Here, focussing on modifications that involve the addition of
Marcin J. Suskiewicz
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Histone H1 Post-Translational Modifications : Update and Future Perspectives [PDF]
, 2020 Histone H1 is the most variable histone and its role at the epigenetic level is less characterized than that of core histones. In vertebrates, H1 is a multigene family, which can encode up to 11 subtypes.
Andrés, Marta +4 more
core +1 more source
Viruses, 2022 Post-translational regulation of proteins has emerged as a central topic of research in the field of functional proteomics. Post-translational modifications (PTMs) dynamically control the activities of proteins and are involved in a wide range of ...
Ramiro Garza-Domínguez +1 more
doaj +1 more source
Pathological Implication of Protein Post-translational Modifications in Cancer [PDF]
, 2022 Protein post-translational modifications (PTMs) profoundly influence protein functions and play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and their crosstalk is linked to many critical signaling events involved
Chen, Ru, Pan, Sheng
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Advances on Post-translational Modifications Involved in Seed Germination
Frontiers in Plant Science, 2021 Seed germination and subsequent seedling establishment are important developmental processes that undergo extremely complex changes of physiological status and are precisely regulated at transcriptional and translational levels.
Feng Yu +3 more
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Large-scale protein-protein post-translational modification extraction with distant supervision and confidence calibrated BioBERT [PDF]
BMC Bioinformatics 23, 4 (2022), 2022 Protein-protein interactions (PPIs) are critical to normal cellular function and are related to many disease pathways. However, only 4% of PPIs are annotated with PTMs in biological knowledge databases such as IntAct, mainly performed through manual curation, which is neither time nor cost-effective.
arxiv +1 more source
Investigation of post-translational modifications in type 2 diabetes
Clinical Proteomics, 2018 The investigation of post-translational modifications (PTMs) plays an important role for the study of type 2 diabetes. The importance of PTMs has been realized with the advancement of analytical techniques.
Bhaswati Chatterjee, Suman S. Thakur
doaj +1 more source
PTMcode v2: a resource for functional associations of post-translational modifications within and between proteins [PDF]
, 2015 The post-translational regulation of proteins is mainly driven by two molecular events, their modification by several types of moieties and their interaction with other proteins. These two processes are interdependent and together are responsible for the
Bork, P. +6 more
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Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]
, 2014 The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat +13 more
core +1 more source