Results 171 to 180 of about 6,865 (203)

Pharmacological postconditioning with the phytoestrogen genistein

Journal of Molecular and Cellular Cardiology, 2007
Estrogens are known to activate the phosphatidyl-inosityl 3-kinase (PI3K)/Akt pathway, which is central in the cardioprotection afforded by ischemic postconditioning. Therefore, our goal was to investigate whether a phytoestrogen, genistein, could induce a pharmacological postconditioning and to investigate potential mechanisms.
Tissier, Renaud, Waintraub, X., Couvreur, N., Gervais, M., Bruneval, P., Mandet, C., Zini, R., Enriquez, B., Bruneval, A., Ghaleh, B.   +9 more
openaire   +3 more sources

Molecular aspects of ischaemic postconditioning

Fundamental & Clinical Pharmacology, 2009
AbstractPreconditioning, a well established phenomenon had been used since 1980s to attenuate ischaemia‐reperfusion induced injury. However, inability to predict the onset of ischaemia in clinical settings led to the discovery of a new concept of postconditioning (PoCo), in 2000s whereby brief repetitive cycles of ischaemia with intermittent ...
Shaminder, Kaur, Amteshwar Singh, Jaggi, Nirmal, Singh   +2 more
openaire   +2 more sources

Preconditioning and postconditioning: United at reperfusion

Pharmacology & Therapeutics, 2007
Despite current optimal treatment, the morbidity and mortality of coronary heart disease (CHD), the leading cause of death worldwide, remains significant, paving the way for the development of novel cardioprotective therapies. Two potential strategies for protecting the heart are ischemic preconditioning (IPC) and ischemic postconditioning (IPost ...
Derek J, Hausenloy, Derek M, Yellon
openaire   +2 more sources

Upgrading the pre- and postcondition technique

1991
This paper gives a reconstruction of the classical pre- and postcondition technique from its roots and extends it with several features. A number of problems in connection with pre- and postcondition specifications are discussed and solutions presented.
openaire   +1 more source

Signalling pathways in ischaemic postconditioning

Thrombosis and Haemostasis, 2009
SummaryCoronary heart disease (CHD) is the leading cause of death globally. Following an acute coronary artery occlusion, timely myocardial reperfusion using either primary percutaneous coronary intervention (PCI) or thrombolytic therapy remains the most effective treatment strategy for reducing myocardial infarct size, preventing left ventricular ...
openaire   +2 more sources

[Effects of combined ischemic postconditioning, remote ischemic postconditioning and naloxone postconditioning on focal cerebral ischemia-reperfusion injury in rats].

Zhonghua yi xue za zhi, 2012
To assess the effects of ischemic postconditioning, remote ischemic postconditioning and naloxone postconditioning on focal cerebral ischemia-reperfusion injury in rats.A total of 110 adult SD rats were randomly divided into 5 groups (n = 22 each).
Yi, Liu, Xu, Liao, Fu-shan, Xue, Ya-chao, Xu, Jun, Xiong, Yu-jing, Yuan, Qiang, Wang, Jian-hua, Liu, Jia-xun, Zhao   +8 more
openaire   +1 more source

Postcondition

2020
openaire   +1 more source

Ischemic Postconditioning During Primary Percutaneous Coronary Intervention

Circulation, 2013
Seung-Hyuk Choi, Joo-Yong Hahn, Sang-Wook Kim   +2 more
exaly  

The Paradigm of Postconditioning to Protect the Heart

Journal of Cellular and Molecular Medicine, 2008
Pasquale Pagliaro, Stefano Geuna, Stefania Raimondo   +2 more
exaly  

postcondition

2011
openaire   +1 more source