Results 151 to 160 of about 10,942,539 (365)

The neuropharmacology of baclofen [PDF]

open access: yes, 1988
AI Shapovalov   +104 more
core   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

open access: yesAdvanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu   +10 more
wiley   +1 more source

A glibenclamide-sensitive TRPM4-mediated component of CA1 excitatory postsynaptic potentials appears in experimental autoimmune encephalomyelitis [PDF]

open access: gold, 2022
Brenna C. Fearey   +7 more
openalex   +1 more source

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

open access: yesAdvanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien   +4 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

open access: yesAdvanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan   +6 more
wiley   +1 more source

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