Results 251 to 260 of about 3,177,241 (350)

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel. [PDF]

Nat Commun
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM.   +5 more
europepmc   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Differential Emodepside Efficacy in Drug-Resistant and Drug-Susceptible <i>Ancylostoma caninum</i> Highlights Variability in Potassium Channel Activity. [PDF]

Trop Med Infect Dis
Jackson CA, McKean EL, Hawdon JM.
europepmc   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury. [PDF]

PLoS One
Sasaki H, Otake K, Takeda K, Tesaki K, Takahashi E, Yasuda J, Matsuda S, Kawasaki A, Watanabe M, Otani K, Okada M, Sekijima M, Yamawaki H, Sasaki N.   +13 more
europepmc   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Complex partial seizures with orofacial involvement in 35 cats: MRI changes, cerebrospinal fluid analysis, voltage-gated potassium channel antibodies and survival. [PDF]

J Feline Med Surg
Flegel T, Matiasek K, Füsser M, Becker LF, Böttcher IC, Dietzel J, Gutmann S, Kalliwoda T, Loderstedt S, Tästensen C, Weiß V, Schulte LP, König JE.   +12 more
europepmc   +1 more source

Edible Pneumatic Battery for Sustained and Repeated Robot Actuation

Advanced Science, EarlyView.
This work presents an edible energy source and valve system to power soft, pneumatically driven edible robots. A chemical reaction between sodium bicarbonate and citric acid generates carbon dioxide gas, and a pressure‐triggered edible valve enables self‐repetitive motion of the edible actuator.
Bokeon Kwak, Shuhang Zhang, Alexander Keller, Qiukai Qi, Jonathan Rossiter, Dario Floreano   +5 more
wiley   +1 more source

Glutamic Acid Decarboxylase Antibody Unexpectedly Detected During Recovery Phase in Three Patients With Voltage-Gated Potassium Channel Antibody-Related Autoimmune Encephalitis. [PDF]

Cureus
Kim AJ, Frem WJ, Bommireddipalli A, Boghoz A, Aylia F, Ozobu I, Haroutunian SG, Williams R, Alkana J, Lee J, Liu AK.   +10 more
europepmc   +1 more source