Results 261 to 270 of about 5,395 (299)

Some Arylacridine Derivatives Possessing Potassium Channel Opening Activity.

ChemInform, 2004
In this study, six new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridinedione derivatives (1-6) were synthesised and their functional effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rat mesenteric arteries were investigated.
Rahime, Simşek, Melike, Ozkan, Emrah, Kismetli, Serdar, Uma, Cihat, Safak   +4 more
openaire   +2 more sources

Effects of potassium channel openers on single potassium channels in mouse skeletal muscle

Naunyn-Schmiedeberg's Archives of Pharmacology, 1990
The patch-clamp technique was used to study the effects of the potassium channel openers cromakalim, pinacidil, RP 49356 and diazoxide on single potassium channels in mouse skeletal muscle. In excised patches in the inside-out configuration, one type of potassium channel, the ATP-sensitive potassium channel, could be activated by internally applied RP ...
R, Weik, B, Neumcke
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Potassium channel openers: pharmacological and clinical aspects

Fundamental & Clinical Pharmacology, 1992
Summary—Opening of plasmalemmal K+ channels leads to cellular hyperpolarization which, in excitable tissues possessing voltage‐dependent Ca2+channels, prevents the opening of such channels and thus prevents excitation. In the last few years, an increasing number of compounds have been identified which elicit their effects by opening K+ channels ...
openaire   +2 more sources

Potassium Channel Openers in Myocardial Ischaemia

Drugs, 2001
Potassium channel openers or agonists represent a novel new class of compounds in the treatment of a range of cardiovascular disorders, particularly angina pectoris and hypertension. Nicorandil is the only clinically available potassium channel opener with antianginal effects, and with comparable efficacy and tolerability to existing antianginal ...
A H, Gomma, H J, Purcell, K M, Fox
openaire   +2 more sources

Potassium channel openers and vascular smooth muscle relaxation

Pharmacology & Therapeutics, 1990
Potassium channel openers comprise a diverse group of chemical agents which open plasma-lemmal K-channels. They show selectivity for smooth muscle, although K-channels in cardiac and skeletal muscle, neurones and the pancreatic beta-cell are also affected at relatively high concentrations.
G, Edwards, A H, Weston
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Peripheral channelopathies as targets for potassium channel openers

Expert Opinion on Investigational Drugs, 2001
Potassium channel openers (KCOs) are important tools that are often used to gain a greater understanding of K(+) channels. Agents that can induce or maintain the opening of K(+) channels also offer a therapeutic approach to controlling of cell excitability and offer a means of producing stability in biological systems. The pathogenesis of a broad range
Lawson, K., Dunne, M. J.
openaire   +3 more sources

Opening the gate in potassium channels

Nature Structural & Molecular Biology, 2004
Structural studies of potassium channels suggest that opening of the gate involves large changes in the intracellular pore aperture, leaving a pore diameter >12 A. A recent mechanistic study on eukaryotic voltage-activated potassium channels points to an alternative picture of opening, including a smaller open pore and possibly a unique hinge or swivel
openaire   +1 more source

Enkephalin opens potassium channels on mammalian central neurones

Nature, 1982
Enkephalin and opiate analgesic drugs exert their effects on the brain by interacting with receptors located on neuronal membranes. An almost immediate consequence of this interaction is an inhibition of action potential discharge of individual nerve cells1.
J T, Williams, T M, Egan, R A, North
openaire   +2 more sources

Potassium Channel Openers and Cardiac Surgery

1997
Cardiac operations offer the unique possibility of precisely planning the time at which the aortic crossclamp will be applied, thereby initiating the period of global ischemia. This provides the opportunity of using the timely implementation of preconditioning strategies as a novel approach to intraoperative myocardial protection based on the ...
Louis P. Perrault, Philippe Menasché
openaire   +1 more source

Potassium Channel Opening and Coronary Vasodilation by Halothane

1994
Publisher Summary This chapter discusses the studies on halothane vasodilation in the presence and absence of glyburide or 5-hydroxydecanoate (5-HD), pharmacological blockers of ATP-sensitive K+ channels (K ATP ) to establish whether halothane relaxes intact epicardial coronary arteries by opening vascular smooth muscle (VSM) K + channels. Halothane
D R, Larach, H G, Schuler, K A, Zangari, R L, McCann   +3 more
openaire   +2 more sources