Results 221 to 230 of about 182,239 (338)

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

How Astragalin Modulates Glucose Uptake and Insulin Secretion in β-Cell Lines. [PDF]

Pharmaceuticals (Basel)
Sulis PM, Mendes ALR, Bunick PWZ, Cesca K, Royer C, Zaniboni BA, Cavalari FC, Pintarelli GB, Dagostin ALA, Silva FRMB.   +9 more
europepmc   +1 more source

Calcium‐activated and voltage‐gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses

Journal of Physiology, 2010
D. Jacobson, Felipe E Mendez, Michael Thompson, Jacqueline O Torres, Olivia Cochet, L. Philipson   +5 more
semanticscholar   +1 more source

Exploring the use of dalfampridine (4‐aminopyridine) for treatment of ataxia in cerebellar stroke

PM&R, EarlyView.
Arjun Kotwal, Prashant Yadav, Veyola Rezkalla, Alison Mautner, Gilbert Siu   +4 more
wiley   +1 more source

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated Na⁺ and K⁺ currents. [PDF]

Pflugers Arch
Ricci C, Sánchez Triviño CA, Rangaswamy U, Tortella L, Sanges R, Boccaccio A, Menini A.   +6 more
europepmc   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, EarlyView.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Recording and modeling of pinched hysteresis loops, the fingerprint of a memristor, in neurons. [PDF]

Sci Rep
Pabst O, Schülke C, Balasingham I, Krauss S, Glover JC, Martinsen ØG.   +5 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

A random-walk-based learning framework to uncover novel gene candidates for Alzheimer's disease therapy. [PDF]

Pac Symp Biocomput
Orlenko A, Li B, Khanjani N, Venkatesan M, Shen L, Ritchie MD, Wang ZP, Obafemi-Ajayi T, Moore JH.   +8 more
europepmc   +1 more source