Results 31 to 40 of about 171,305 (316)

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains [PDF]

, 2015
Voltage-gated channels open paths for ion permeation upon changes in membrane potential, but how voltage changes are coupled to gating is not entirely understood.
Barros de la Roza, Francisco, Fernández Trillo, Jorge, Gómez Posada, Juan Camilo, Leipscher, Ulrike, Loerinczi, Eva, Pardo Fernández, Luis Ángel, Peña Cortines, María del Pilar de la, Stuehmer, Walter, Tomczak, Adam P.   +8 more
core   +1 more source

Outward Rectification of Voltage-Gated K+ Channels Evolved at Least Twice in Life History. [PDF]

PLoS ONE, 2015
Voltage-gated potassium (K+) channels are present in all living systems. Despite high structural similarities in the transmembrane domains (TMD), this K+ channel type segregates into at least two main functional categories-hyperpolarization-activated ...
Janin Riedelsberger, Ingo Dreyer, Wendy Gonzalez   +2 more
doaj   +1 more source

Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels

Journal of Biomedical Sciences, 2016
Resveratrol, a phytoalexin found in grapes and red wine, exhibits diverse pharmacological activities. However, relatively little is known about whether resveratrol modulates the ion channels in cortical neurons.
Ya-Jean Wang, M. Chan, Linyi Chen, Sheng-Nan Wu, Hwei-Hsien Chen   +4 more
semanticscholar   +1 more source

Role of potassium conductance in mechanisms of exrtacellular atp impact on the contractive activity of vascular smooth muscle cells

Бюллетень сибирской медицины, 2017
The purpose of this work is to study the influence of extracellular ATP (adenosine-3-phosphate), which is an activator of purinergic receptors, on contractive activity of rat aortic ring segments precontracted by α1-adrenoreceptors activation with ...
S. N. Orlov, L. V. Smagliy, S. V. Gusakova, V. S. Rydchenko, Yu. G. Birulina, A. N. Baikov, V. N. Vasiliyev, G. A. Sukhanova, T. S. Fedorova, T. V. Lasukova   +9 more
doaj   +1 more source

Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]

, 2018
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core   +1 more source

An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels*

Journal of Biological Chemistry, 2015
Background: Neuronal axons use dense clusters of voltage-gated ion channels to conduct rapid electrical signals called action potentials. Results: We mapped sites on a cytoskeletal protein, ankyrin-G, which binds and clusters sodium and potassium ...
Mingxuan Xu, E. Cooper
semanticscholar   +1 more source

Behavior of ion channels controlled by electric potential difference and of Toll-type receptors in neuropathic pain pathophysiology

Revista Dor
BACKGROUND AND OBJECTIVES: Neuropathic pain is a severe and refractory medical condition, for which only partially effective treatments are currently available.
André Prato Schmidt, Sérgio Renato Guimarães Schmidt   +1 more
doaj   +1 more source

Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation

Nature Communications, 2020
In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism during voltage-
Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli McFarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui   +14 more
doaj   +1 more source

Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes

Marine Drugs, 2020
Recently, Conorfamide-Sr3 (CNF-Sr3) was isolated from the venom of Conus spurius and was demonstrated to have an inhibitory concentration-dependent effect on the Shaker K+ channel.
Estuardo López-Vera, Luis Martínez-Hernández, Manuel B. Aguilar, Elisa Carrillo, Joanna Gajewiak   +4 more
doaj   +1 more source

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. [PDF]

PLoS ONE, 2013
Kv11.1 potassium channels are important for regulation of the normal rhythm of the heartbeat. Reduced activity of Kv11.1 channels causes long QT syndrome type 2, a disorder that increases the risk of cardiac arrhythmias and sudden cardiac arrest.
Chai Ann Ng, Ying Ke, Matthew D Perry, Peter S Tan, Adam P Hill, Jamie I Vandenberg   +5 more
doaj   +1 more source