MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe. [PDF]
Cancer SciMASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Wang K, Fu Z, Xiong C, Zhang J, Luo Q.
europepmc +2 more sources
Regulation of PP2A by Sphingolipid Metabolism and Signaling [PDF]
Frontiers in Oncology, 2015 Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is a primary regulator of cellular proliferation through targeting of proliferative kinases, cell cycle regulators, and apoptosis inhibitors.
Joshua eOaks, Besim eOgretmen
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Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. [PDF]
, 2013 Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits.
Clarke, Steven G +3 more
core +21 more sources
The Journal of Clinical InvestigationDysregulated eIF4E-dependent translation is a central driver of tumorigenesis and therapy resistance. eIF4E-binding proteins (4E-BP1/2/3) are major negative regulators of eIF4E-dependent translation that are inactivated in tumors through inhibitory ...
Michelle A. Lum +15 more
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Metformin induces senescence of colorectal cancer cells through PP2A/AKT pathway
Di-san junyi daxue xuebao, 2021 Objective To determine whether metformin(Met) inhibits the proliferation of colorectal cancer cells by inducing cell senescence, and to preliminarily explore the underlying mechanism.
YANG Jianying +7 more
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The overlooked greatwall: a new perspective on mitotic control [PDF]
Open Biology, 2012 The role of the dual specificity protein phosphatase, Cdc25, in activating the cyclin-dependent kinase-cyclin B complex (Cdk1-CycB) by overcoming the inhibitory Wee1 kinase is a long-established principle for mitotic entry.
David M. Glover
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Adventures of the undead at kinetochores
Molecular & Cellular Oncology, 2021 At the metaphase-to-anaphase transition, phosphatase activity feeds back to reverse early mitotic phosphorylation events. Our recent work indicates that the pseudokinase domain of the spindle checkpoint protein BUB1 (Budding Uninhibited by Benzimidazoles
Sabine Elowe
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A PP2A-B56—Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I
Cells, 2020 Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes—oocytes and sperm—with the correct number of chromosomes.
Leonor Keating +2 more
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The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
Cells, 2020 The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer.
Raffaella Pippa, Maria D. Odero
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Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia. [PDF]
PLoS ONE, 2012 The hypoxic microenvironment of glioblastoma multiforme (GBM) is thought to increase resistance to cancer therapies. Recent evidence suggests that hypoxia induces protein phosphatase 2A (PP2A), a regulator of cell cycle and cell death.
Christoph P Hofstetter +8 more
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