Results 101 to 110 of about 55,976 (264)
PP2A: Unveiling a Reluctant Tumor Suppressor [PDF]
Cell, 2007 Although evidence has suggested that the serine/threonine protein phosphatase 2A (PP2A) might be a tumor suppressor protein, it has been difficult to pin down its role in tumor suppression because it acts in a wide variety of signaling pathways. Recent findings, including work in this issue by Junttila et al.
openaire +2 more sources
Neoplasia: An International Journal for Oncology Research, 2009 Protein phosphatase 2A (PP2A) functions as a potent tumor suppressor, but its mechanism(s) remains enigmatic. Specific disruption of PP2A by either expression of SV40 small tumor antigen or depletion of endogenous PP2A/C by RNA interference inhibits Ku ...
Qinhong Wang +4 more
doaj +1 more source
Phospho-Akt expression is high in a subset of triple negative breast cancer patients [PDF]
, 2014 The most commonly used biomarkers to predict the response of breast cancer patients to therapy are oestrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2).
Baldacchino, Shawn +6 more
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The Journal of Physiology, EarlyView.Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev +7 more
wiley +1 more source
Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition [PDF]
, 2022 Yitong Li +9 more
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Specification of spatial relationships in directed graphs of cell signaling networks [PDF]
, 2008 Graph theory provides a useful and powerful tool for the analysis of cellular signaling networks. Intracellular components such as cytoplasmic signaling proteins, transcription factors and genes are connected by links, representing various types of ...
Azi Lipshtat +2 more
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C3G mediated suppression of malignant transformation involves activation of PP2A phosphatases at the subcortical actin cytoskeleton [PDF]
, 2012 In previous work, we demonstrated that C3G suppresses Ras oncogenic transformation by a mechanism involving inhibition of ERK phosphorylation. Here we present evidences indicating that this suppression mechanism is mediated, at least in part, by serine ...
Ayoub, N. +9 more
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New Phytologist, Volume 249, Issue 3, Page 1253-1267, February 2026.Summary Obtaining sufficient light for photosynthesis and avoiding desiccation are two key challenges faced by seedlings during early establishment. Perception of light quality via specialised photoreceptors signals the availability of sunlight for photosynthesis.
Mathilda Gustavsson +3 more
wiley +1 more source
Respiratory Research, 2019 Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic inflammation and lung function impairment in COPD have been identified in LC ...
Cassandra P. Nader +3 more
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Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study [PDF]
, 2008 Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form.
Barrett, Tracey +7 more
core +3 more sources