Results 11 to 20 of about 55,976 (264)

PP2A-Mediated Anticancer Therapy [PDF]

Gastroenterology Research and Practice, 2013
PP2A is a family of mammalian serine/threonine phosphatases that is involved in the control of many cellular functions including protein synthesis, cellular signaling, cell cycle determination, apoptosis, metabolism, and stress responses through the ...
Weibo Chen, Zhongxia Wang, Chunping Jiang, Yitao Ding   +3 more
doaj   +4 more sources

Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting [PDF]

The EMBO Journal, 2021
Protein phosphatase 2A (PP2A) is an abundant phosphoprotein phosphatase that acts as a tumor suppressor. For this reason, compounds able to activate PP2A are attractive anticancer agents. The compounds iHAP1 and DT-061 have recently been reported to selectively stabilize specific PP2A-B56 complexes to mediate cell killing.
Gianmatteo Vit, Joana Duro, Girish Rajendraprasad, Emil Peter Thrane Hertz, Lya Katrine Kauffeldt Holland, Melanie Weisser, Brennan C McEwan, Blanca López‐Méndez, Guillermo Montoya, Niels Mailand, Kenji Maeda, Arminja N. Kettenbach, Marin Barišić, Jakob Nilsson   +13 more
  +10 more sources

The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A [PDF]

Frontiers in Molecular Biosciences, 2021
Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer.
Chandan Thapa, Chandan Thapa, Chandan Thapa, Pekka Roivas, Pekka Roivas, Tatu Haataja, Tatu Haataja, Tatu Haataja, Perttu Permi, Perttu Permi, Ulla Pentikäinen, Ulla Pentikäinen   +11 more
doaj   +6 more sources

Interaction mechanism of endogenous PP2A inhibitor protein ENSA with PP2A [PDF]

The FEBS Journal, 2021
The vast diversity of protein phosphatase 2A (PP2A) holoenzyme composition ensures its multifaceted role in the regulation of cellular growth and signal transduction. In several pathological conditions, such as cancer, PP2A is inhibited by endogenous inhibitor proteins. Several PP2A inhibitor proteins have been identified, one of which is α‐endosulfine
Roivas, Pekka, Haataja, Tatu, Permi, Perttu, Pentikäinen, Ulla, Thapa, Chandan   +5 more
openaire   +6 more sources

PP2A and tumor radiotherapy [PDF]

Hereditas, 2020
AbstractProtein phosphatase 2A (PP2A) is a serine/threonine phosphatase that serves as a key regulator of cellular physiology in the context of apoptosis, mitosis, and DNA damage responses. Canonically, PP2A functions as a tumor suppressor gene. However, recent evidence suggests that inhibiting PP2A activity in tumor cells may represent a viable ...
Xiao Lei, Na Ma, Lehui Du, Yanjie Liang, Pei Zhang, Yanan Han, Baolin Qu   +6 more
openaire   +3 more sources

PP2A Regulatory Subunit PP2A-B′ Counteracts S6K Phosphorylation [PDF]

Cell Metabolism, 2010
The insulin/TOR signaling pathway plays a crucial role in animal homeostasis, sensing nutrient status to regulate organismal growth and metabolism. We identify here the Drosophila B' regulatory subunit of PP2A (PP2A-B') as a novel, conserved component of the insulin pathway that specifically targets the PP2A holoenzyme to dephosphorylate S6K.
Hahn, Katrin, Miranda, Merce, Francis, Víctor A., Vendrell, Joan, Zorzano, Antonio, Teleman, Aurelio A.   +5 more
openaire   +2 more sources

PP2A Regulates HDAC4 Nuclear Import [PDF]

Molecular Biology of the Cell, 2008
Different signal-regulated serine/threonine kinases phosphorylate class II histone deacetylases (HDACs) to promote nuclear export, cytosolic accumulation, and activation of gene transcription. However, little is known about mechanisms operating in the opposite direction, which, possibly through phosphatases, should promote class II HDACs nuclear entry ...
BRANCOLINI, Claudio, CERNOTTA, Nadia, DELLO RUSSO C., FOTI, Carmela, GALLINARI P, ORSATTI L., PALLAORO M., PARONI, Gabriela, STEINKUHLER C, TALAMO F.   +9 more
openaire   +3 more sources

Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases

Medicina, 2023
New disease targets and medicinal chemistry approaches are urgently needed to develop novel therapeutic strategies for treating pulmonary diseases.
Howard Yu, Sahil Zaveri, Zeeshan Sattar, Michael Schaible, Brais Perez Gandara, Anwar Uddin, Lucas R. McGarvey, Michael Ohlmeyer, Patrick Geraghty   +8 more
doaj   +1 more source

PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production

Viruses, 2019
Protein phosphatase 2A (PP2A), a major serine/threonine phosphatase in mammalian cells, is known to regulate the kinase-driven intracellular signaling pathways.
Jiayu Xu, Lu Zhang, Yunfei Xu, He Zhang, Junxin Gao, Qian Wang, Zhijun Tian, Lv Xuan, Hongyan Chen, Yue Wang   +9 more
doaj   +1 more source

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita, Hallahan, Dennis E., Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Sharma, Girdhar G., Zobel, Cheri L.   +6 more
core   +3 more sources