Results 21 to 30 of about 55,976 (264)
Inhibitor-1 and -2 of PP2A have preference between PP2A complexes [PDF]
Biochemical and Biophysical Research Communications, 2015 Protein phosphatase 2A (PP2A) forms tens of kinds of complexes with different substrate specificity and functions by using various regulatory B subunits. But how these complexes' activities are regulated separately is not well understood. Here we showed unequal enzyme inhibition of each form by two proteinous PP2A inhibitors, I1(PP2A) and I2(PP2A ...
Hirotsugu, Hino +2 more
openaire +2 more sources
Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development [PDF]
, 2009 Acquisition of epidermal barrier function occurs late in mouse gestation. Several days before birth a wave of barrier acquisition sweeps across murine fetal skin, converging on dorsal and ventral midlines.
Byrne, C +3 more
core +2 more sources
Cells, 2019 Adenylyl cyclase type 5 (AC5), as the principal isoform expressed in striatal medium spiny neurons (MSNs), is essential for the integration of both stimulatory and inhibitory midbrain signals that initiate from dopaminergic G protein-coupled receptor ...
Trevor B. Doyle +8 more
doaj +1 more source
Autocrine Transforming Growth Factor β Signaling Regulates Extracellular Signal-regulated Kinase 1/2 Phosphorylation via Modulation of Protein Phosphatase 2A Expression in Scleroderma Fibroblasts [PDF]
, 2010 BACKGROUND. During scleroderma (SSc) pathogenesis, fibroblasts acquire an activated phenotype characterized by enhanced production of extracellular matrix (ECM) and constitutive activation of several major signaling pathways including extracellular ...
Bujor, Andreea M. +4 more
core +3 more sources
PP2A inactivation by ROS accumulation [PDF]
Blood, 2014 In this issue of Blood, Low and colleagues show that reactive oxygen species (ROS)–mediated phosphorylation of Bcl-2 overcomes chemoresistance in hematopoietic malignancies and other cancers and that this function is mediated by selective nitration of Y289 on the Bcl-2–bound B56δ subunit of protein phosphatase 2A (PP2A), which interferes with the ...
Shingo, Nakahata, Kazuhiro, Morishita
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Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]
, 2009 We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon +54 more
core +3 more sources
PP2A Activators Stabilize PP2A Complexes with Differing Specificities [PDF]
Cancer Discovery, 2020 Abstract Anticancer PP2A activators facilitated assembly of holoenzymes with unique regulatory subunits.
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PP2A: The Wolf in Sheep’s Clothing? [PDF]
Cancers, 2015 Protein Phosphatase 2A (PP2A) is a major serine/threonine phosphatase in cells. It consists of a catalytic subunit (C), a structural subunit (A), and a regulatory/variable B-type subunit. PP2A has a critical role to play in homeostasis where its predominant function is as a phosphatase that regulates the major cell signaling pathways in cells ...
Kiely, Maeve, Kiely, Patrick A.
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Targeting PP2A for cancer therapeutic modulation
Cancer Biology & Medicine, 2022 Protein phosphatases play essential roles as negative regulators of kinases and signaling cascades involved in cytoskeletal organization. Protein phosphatase 2A (PP2A) is highly conserved and is the predominant serine/threonine phosphatase in the nervous system, constituting more than 70% of all neuronal phosphatases.
Halle Ronk +3 more
openaire +3 more sources
Protein Phosphatase 2A: Role in T Cells and Diseases
Journal of Immunology Research, 2023 Protein phosphatase 2A (PP2A) is a serine–threonine phosphatase that plays an important role in the regulation of cell proliferation and signal transduction.
Suyasha Roy, Lalit Batra
doaj +1 more source