(E)-3-(4-(tert-Butyl)Phenyl)-N-Isobutyl-2-Methylacrylamide Suppresses Adipogenesis in High-Fat-Fed Mice [PDF]
Acta Poloniae Pharmaceutica, 2023 Obesity is caused by excessive adipogenesis and leads to metabolic diseases such as diabetes, hypertension, and degenerative arthritis. Therefore, there is an ever-increasing need to identify new anti-obesity compounds.
Jinyoung Hur +6 more
doaj +1 more source
L-carnitine administration effects on AMPK, APPL1 and PPARγ genes expression in the liver and serum adiponectin levels and HOMA-IR in type 2 diabetes rat model induced by STZ and nicotinamide [PDF]
The Ukrainian Biochemical Journal, 2020 Diabetes is a chronic disease and a public health problem globally. L-Carnitine is synthesized in the liver, promotes fatty acids oxidation and currently is used as a supplement against weight gain.
B. Shahouzehi +2 more
doaj +1 more source
Evaluation of the Effect of Co-administration of IRAK Inhibitor and Pioglitazone on PPAR-γ, GLUT-4, TNF-α, and Leptin Genes Expression in Adipose Tissue of Insulin-resistant Mice [PDF]
Journal of Kerman University of Medical Sciences, 2021 Background: The worldwide prevalence of diabetes is increasing. Diabetes is a complex disease that results from impaired secretion of insulin or insulin resistance.
Saeedeh Moinaldini +3 more
doaj +1 more source
The effect of eight-week resistance training and consumption of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in the myocardial infarction model [PDF]
Journal of Shahrekord University of Medical Sciences, 2022 Background and aims: The consumption of grape seed nanoparticles extract can control cardiovascular risk factors. Exercise plays a protective role against cardiovascular disease.
Ebrahim Khaki +3 more
doaj +1 more source
Cancer Biology & Medicine, 2023 Objective: Polyploid giant cancer cells (PGCCs) with daughter cells express epithelial–mesenchymal transition (EMT)-associated proteins. Highly malignant tumor cells with EMT properties can transdifferentiate into mature tumor cells.
Kexin Zhang +4 more
doaj +1 more source
Cell Communication and Signaling, 2022 Peroxisome proliferator-activated receptor gamma (PPARγ) is an enhancer of Treg responses, but the mechanisms remain elusive. This study aimed to solve this problem in view of cellular metabolism.
Yu-meng Miao +7 more
semanticscholar +1 more source
Oxidative Medicine and Cellular Longevity, 2022 Sepsis is a systemic inflammatory response syndrome caused by a dysregulated host response to infection. Peroxisome proliferator‐activated receptor gamma (PPARγ) exerts anti‐inflammatory and antioxidative properties.
Zeyu Li +9 more
semanticscholar +1 more source
PPARγ and TGFβ—Major Regulators of Metabolism, Inflammation, and Fibrosis in the Lungs and Kidneys
International Journal of Molecular Sciences, 2021 Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor, initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism.
G. Kökény, L. Calvier, G. Hansmann
semanticscholar +1 more source
Inhibitory effect of PPARγ on NLRP3 inflammasome activation
Theranostics, 2021 Rationale: Stimulation of the NLRP3 inflammasome by metabolic byproducts is known to result in inflammatory responses and metabolic diseases. However, how the host controls aberrant NLRP3 inflammasome activation remains unclear.
Ching-Chun Yang +7 more
semanticscholar +1 more source
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
Nature Communications, 2021 Group 2 innate lymphoid cells (ILC2s) play a critical role in protection against helminths and in diverse inflammatory diseases by responding to soluble factors such as the alarmin IL-33, that is often overexpressed in cancer.
G. Ercolano +16 more
semanticscholar +1 more source