Results 121 to 130 of about 121,549 (307)
Advanced Science, EarlyView.This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan +9 more
wiley +1 more source
Drug Design, Development and Therapy, 2021 Chunyan Wang,1,2,* Zhengyun Chen,1,* Xianlei Zhao,2,* Cuicui Lin,2 Shenghui Hong,3 Yuhan Lou,2 Xiaomeng Shi,1 Mengdan Zhao,1 Xiaohang Yang,1,2 Min-Xin Guan,2 Yongmei Xi1,2 1The Women’s Hospital, Zhejiang University School of Medicine ...
Wang C +10 more
doaj
Encounter complexes and dimensionality reduction in protein-protein association [PDF]
, 2014 An outstanding challenge has been to understand the mechanism whereby proteins associate. We report here the results of exhaustively sampling the conformational space in protein–protein association using a physics-based energy function.
Beglov, D. +9 more
core +2 more sources
Environmental Health Perspectives, 2019 Background: Phthalates are environmental contaminants commonly used as plasticizers in polyvinyl chloride (PVC) products. Recently, exposure to phthalates has been associated with preterm birth, low birth weight, and pregnancy loss.
Hussein Shoaito +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen +12 more
wiley +1 more source
Tissue- and site-specific effects of PPARγ activation and its role in chronic inflammation [PDF]
, 2011 Developmental programming, metabolism, immune function and tissue homeostasis in multicellular organisms are regulated by a plethora of stimuli. Transcription factors (TFs) convert incoming signals to appropriate transcriptional responses of the genome.
Pott, Sebastian
core +1 more source
Theranostics, 2018 Rationale: It has been reported that peroxisome proliferator activated receptor γ (PPARγ) level decreases significantly in the brains of Alzheimer's disease (AD) patients and mice models, while the mechanism is unclear.
Mu Zhang +13 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He +7 more
wiley +1 more source
MiR-27b targets PPARγ to inhibit growth, tumor progression, and the inflammatory response in neuroblastoma cells [PDF]
, 2012 The PPARγ nuclear receptor pathway is involved in cancer, but it appears to have both tumor suppressor and oncogenic functions. In neuroblastoma cells, miR-27b targets the 3′UTR of PPARγ and inhibits its mRNA and protein expression.
Drakaki, Alexandra +3 more
core +1 more source
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer
Nature Communications, 2017 Muscle-invasive bladder cancer (MIBC) is an aggressive disease with limited therapeutic options. Although immunotherapies are approved for MIBC, the majority of patients fail to respond, suggesting existence of complementary immune evasion mechanisms ...
M. Korpal +38 more
semanticscholar +1 more source