Results 151 to 160 of about 121,549 (307)

Qing-Luo-Yin Eased Adjuvant-Induced Arthritis by Inhibiting SIRT1-Controlled Visfatin Production in White Adipose Tissues

Journal of Inflammation Research
Dan-Dan Wang,1,2,* Meng-Ke Song,1,3,* Qin Yin,1,2 Wen-Gang Chen,2 Opeyemi Joshua Olatunji,4 Kui Yang,3 Jian Zuo1,3,5 1Xin’an Medicine Research Center, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, 241000 ...
Wang DD, Song MK, Yin Q, Chen WG, Olatunji OJ, Yang K, Zuo J   +6 more
doaj  

Per‐ and polyfluoroalkyl substances and hand osteoarthritis: data from the Osteoarthritis Initiative

Arthritis &Rheumatology, Accepted Article.
Objective To explore whether biological levels of specific per‐ and polyfluoroalkyl substances (PFAS) and a mixture of PFAS – reflecting the overall effect and accounting for correlations among each PFAS – relate to incident hand osteoarthritis (HOA) and progression.
Jeffrey B. Driban, Lisa B. Rokoff, Bing Lu, Timothy E. McAlindon, Charles B. Eaton, Mary B. Roberts, Diana Mathes, Colleen Lestician, Zhijin Carrie Xu, Zhihua Tina Fan, Shawn P. O'Leary, Ida K. Haugen, Jérémie Sellam, Alice Courties, Abby F. Fleisch   +14 more
wiley   +1 more source

Bergenin, Acting as an Agonist of PPARγ, Ameliorates Experimental Colitis in Mice through Improving Expression of SIRT1, and Therefore Inhibiting NF-κB-Mediated Macrophage Activation

Frontiers in Pharmacology, 2018
Bergenin, isolated from the herb of Saxifraga stolonifera Curt. (Hu-Er-Cao), has anti-inflammatory, antitussive and wound healing activities. The aim of the present study was to identify the effect of bergenin on experimental colitis, and explored the ...
Kai Wang, Yun-fan Li, Q. Lv, Xi-ming Li, Yue Dai, Zhifeng Wei   +5 more
semanticscholar   +1 more source

Adipocytes in Aortic Stenosis: Association With Clinical and Morphological Indices

Clinical Anatomy, EarlyView.
ABSTRACT Recently, great attention has been given to understanding the new pathogenetic mechanisms underlying aortic stenosis (AS). The study aims to understand the role of mature adipocytes in AS and their association with histologic, clinical, and echocardiographic data, an area previously overlooked in AS research.
Elena Zoico, Tanaz Saatchi, Silvia Urbani, Vanni Rizzatti, Gloria Mazzali, Francesco Fantin, Silvia Faccioli, Alessandro Gavras, Mauro Zamboni, Anna Giani   +9 more
wiley   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Chuanxiong Renshen Decoction Inhibits Alzheimer’s Disease Neuroinflammation by Regulating PPARγ/NF-κB Pathway

Drug Design, Development and Therapy
Jinling Hou,1,* Xiaoyan Wang,1,* Jian Zhang,1 Zhuojun Shen,1 Xiang Li,2 Yuanxiao Yang2 1School of Pharmacy, Hangzhou Medical College, Hangzhou, People’s Republic of China; 2School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical ...
Hou J, Wang X, Zhang J, Shen Z, Li X, Yang Y   +5 more
doaj  

Peroxisome proliferator-activated receptors gama ameliorates liver fibrosis in non-alcoholic fatty liver disease by inhibiting TGF-β/Smad signaling activation

Frigid Zone Medicine
Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by a progressive decline in liver function, leading to disruptions in liver integrity and metabolic function, resulting in lipid deposition and excessive accumulation of ...
Zhang Qingwei, Zhao Wenjie, Sun Zeqi, Dong Xinxin, Zhu Liwei, Zhang Zhen, Chen Ximing, Hu Yingying, Du Menghan, Li Jiamin, Zhang Yong   +10 more
doaj   +1 more source

Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells

International Journal of Breast Cancer, 2013
γ-Tocotrienol is a natural vitamin E that displays potent anticancer activity, and previous studies suggest that these effects involve alterations in PPARγ activity.
Abhita Malaviya, Paul W. Sylvester
doaj   +1 more source

Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages [PDF]

, 2019
学位記番号 ...
Bu, Yun, ブ, イュン, 歩, 云
core  

Computer‐Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism

Food Bioengineering, EarlyView.
ABSTRACT This study investigated the lipid‐lowering effects and intervention mechanisms of structurally diverse functional oligosaccharides on non‐alcoholic fatty liver disease (NAFLD). By integrating computational tools such as molecular docking and molecular dynamics simulations (MDS), a comprehensive “in silico‐in vitro‐in vivo” tri‐dimensional ...
Rui Jing, Shanshan Deng, Mengyao Zhao, Liming Zhao   +3 more
wiley   +1 more source