The Effects of Intra-Ductal Mammary Administration of Orexin-A Antagonist (SB-334867) on the PPARγ and SREBP1c Gene Expression and Serum Adiponectin Levels in Lactating Rats [PDF]
International Journal of Basic Science in Medicine, 2022 Introduction: Orexin A and adiponectin are involved in controlling metabolism and energy distribution in the body during lactation. Lactation is a process with high demand for lipid synthesis.
Sepideh babaei garmkhani +1 more
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Biological Rationale for the Use of PPARγ Agonists in Glioblastoma [PDF]
Frontiers in Oncology, 2014 Glioblastoma multiforme (GBM) is the most common primary intrinsic central nervous system tumor and has an extremely poor overall survival with only 10% patients being alive after 5 years. There has been interesting preliminary evidence suggesting that diabetic patients receiving peroxisome proliferator-activated receptor gamma (PPARγ) agonists, a ...
Hayley Patricia Ellis +2 more
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Biomedicines, 2023 Oleuropein (OLE), a main constituent of olive, displays a pleiotropic beneficial dynamic in health and disease, based mainly on its antioxidant and hypolipidemic properties, and its capacity to protect myocardium during ischemia. Furthermore, OLE activates peroxisome proliferator-activated receptor (PPARα) in neurons and astrocytes, providing
Foteini Malliou +9 more
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Gene Silencing of Toll-like Receptor 2 Gene Expression as a Tactic to Control Mycobacterium Tuberculosis and Granuloma Formation [PDF]
Archives of Razi Institute, 2022 Mycobacterium tuberculosis (MT) is the causative agent of tuberculosis (TB) in humans. Tuberculosis is one of the top 10 causes of mortality worldwide, resulting in 1.8 million deaths and 10.4 million new cases in 2016.
M. A Nama
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PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
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Shockwaves Suppress Adipocyte Differentiation via Decrease in PPARγ
Cells, 2020 Adipogenesis is a crucial cellular process that contributes to the expansion of adipose tissue in obesity. Shockwaves are mechanical stimuli that transmit signals to cause biological responses.
Wonkyoung Cho +3 more
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PPARγ: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland [PDF]
International Journal of Ophthalmology, 2020 AIM: To investigate the regulatory roles of the members of the peroxisome proliferator-activated receptor (PPAR) family in lacrimal gland dysfunction under conditions of desiccating stress or diabetes.
Peng-Yue Mu +4 more
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PPARβ/δ and PPARγ maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone [PDF]
Frontiers in Cellular Neuroscience, 2015 The subventricular zone (SVZ) is one of the main niches of neural stem cells in the adult mammalian brain. Stem and precursor cells in this region are the source for neurogenesis and oligodendrogesis, mainly in the olfactory bulb and corpus callosum, respectively.
Carolina eBernal +4 more
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The FASEB Journal, 2021 Peroxisome proliferator‐activated receptor gamma (PPARγ) is a master regulator of adipogenesis and lipogenesis. To understand its roles in fiber formation and fat deposition in skeletal muscle, we successfully generated muscle‐specific overexpression of ...
H. Gu +15 more
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Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in FABP4 induction [PDF]
, 2020 Adipocyte differentiation of bovine adipose-derived stem cells (ASC) was induced by foetal bovine serum (FBS), biotin, pantothenic acid, insulin, rosiglitazone, dexamethasone and 3-isobutyl-1-methylxanthine, followed by incubation in different media to ...
Aschenbach, Jörg R. +6 more
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