Results 21 to 30 of about 121,549 (307)
Theranostics, 2021 Background: Peroxisome proliferator-activated receptor gamma (PPARγ) has the ability to counter Th17 responses, but the full mechanisms remain elusive. Herein, we aimed to elucidate this process in view of cellular metabolism, especially glutaminolysis ...
Yu-meng Miao +6 more
semanticscholar +1 more source
PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS [PDF]
Frontiers in Pharmacology, 2014 Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Epoxyeicosatrienoic acids (EETs) are biologically active metabolites of arachidonic acids capable of activating protective cellular pathways in response to stress stimuli. EETs evoke a plethora
Victor eSamokhvalov +8 more
openaire +3 more sources
Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice
Endocrine Connections, 2021 Exercise has been recommended as an important strategy to impro ve glucose metabolism in obesity. Adipose tissue fibrosis is associated with inflammati on and is implicated in glucose metabolism disturbance and insulin resistance in obesit y.
Liangming Li +10 more
doaj +1 more source
Kinetic characterization of selective peroxisome-proliferator-activated receptor gamma modulators in vitro [PDF]
, 2012 Background: The ligand-activated transcription factor, peroxisome-proliferator-activated receptor gamma (PPARγ), has been shown to play an essential role in immunosuppression during sepsis.
Brüne, Bernhard +6 more
core +1 more source
The use of telmisartan in patients with refractory arterial hypertension and obesity
Кардиоваскулярная терапия и профилактика, 2019 Aim. To evaluate the effectiveness of telmisartan as a component of triple antihypertensive therapy in patients with obesity and refractory arterial hypertension.Material and methods.
I. Е. Deneka +2 more
doaj +1 more source
PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]
, 2017 How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M +8 more
core +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance It is still a great challenge to identify novel therapeutic strategies for breast cancer, especially for those with treatment resistance. It was demonstrated here that nuclear receptor Nur77 was an effective drug target for breast cancer and
Peng-bo Yang +18 more
semanticscholar +1 more source
Localization of peroxisome proliferator-activated receptor alpha (PPARα) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the Ca2+-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus [PDF]
Frontiers in Neuroanatomy, 2014 The N-acylethanolamines (NAEs), oleoylethanolamide (OEA) and palmithylethanolamide (PEA) are known to be endogenous ligands of PPARα receptors, and their presence requires the activation of a specific phospholipase D (NAPE-PLD) associated with intracellular Ca(2+) fluxes.
Rivera, Patricia +7 more
openaire +7 more sources
Renal Failure, 2020 Objective Nephrotoxicity is the main side effect of cyclosporine A and finding an effective combating method is urgent. The present study investigates the improving effect of erythropoietin (EPO) on cyclosporine A induce renal injury in rats and further ...
Bin Liu, Ping Tan
doaj +1 more source
Therapeutic potential of PPARγ natural agonists in liver diseases
Journal of Cellular and Molecular Medicine, 2020 Peroxisome proliferator‐activated receptor gamma (PPARγ) is a vital subtype of the PPAR family. The biological functions are complex and diverse. PPARγ plays a significant role in protecting the liver from inflammation, oxidation, fibrosis, fatty liver ...
Liwei Wu, Chuanyong Guo, Jianye Wu
semanticscholar +1 more source