Results 1 to 10 of about 72,395 (103)

Development of a promising PPAR signaling pathway-related prognostic prediction model for hepatocellular carcinoma [PDF]

Scientific Reports
AbstractThe peroxisome proliferator-activated receptor (PPAR) signaling pathway plays a crucial role in systemic cell metabolism, energy homeostasis and immune response inhibition. However, its significance in hepatocellular carcinoma (HCC) has not been well documented.
Li Lanjuan, Qingmiao Shi
exaly   +5 more sources

TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis. [PDF]

Lipids Health Dis, 2021
Abstract Background To investigate the roles of the transcription factors twist family bHLH transcription factor 1 (TWIST1), twist family bHLH transcription factor 2 (TWIST2), and peroxisome proliferator activated receptor gamma (PPARγ) in the progression of nonalcoholic steatohepatitis.
Zhang Y, Ge X, Li Y, Zhang B, Wang P, Hao M, Gao P, Zhao Y, Sun T, Lu S, Ma W.   +10 more
europepmc   +5 more sources

Didymin Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the PPAR Signaling Pathway. [PDF]

Yonsei Med J, 2022
Cerebral ischemia-reperfusion (IR) injury is a severe secondary injury induced by reperfusion after stroke. Didymin has been reported to have a protective effect on intracerebral hemorrhage. However, the underlying mechanism of didymin on regulating cerebral IR injury remains largely unknown.A rat cerebral IR model and oxygen-glucose deprivation ...
Li Q, Zhang H, Liu X.
europepmc   +3 more sources

Role of Apolipoprotein A1 in PPAR Signaling Pathway for Nonalcoholic Fatty Liver Disease. [PDF]

PPAR Res, 2022
Peroxisome proliferator-activated receptors (PPARs) have been suggested to play crucial roles in the pathology of NAFLD with a vague understanding of the underlying mechanism. Here, we integrated large-scale literature data and clinical data to explore the potential role of the PPAR-APOA1 signaling pathway in the pathology of NAFLD.
Chen C, Li H, Song J, Zhang C, Li M, Mao Y, Liu A, Du J.   +7 more
europepmc   +5 more sources

HSPD1 regulates angiotensin II‑induced atrial fibrillation via the PPAR signaling pathway. [PDF]

Mol Med Rep
Atrial fibrillation (AF) is a multifactorial condition, and understanding its molecular mechanisms is key for developing targeted therapies. The present study aimed to investigate the role of heat shock protein D1 (HSPD1) in the pathogenesis of AF, particularly in angiotensin II (Ang II)‑induced cardiac fibroblasts (CFs). Differentially expressed genes
Zhou Y, Zhang L, Zhou S, Zhang W, Gong Q, Xu N, Wang J, Zhang Z, Chen N.   +8 more
europepmc   +4 more sources

Fasting and Refeeding Affect the Goose Liver Transcriptome Mainly Through the PPAR Signaling Pathway. [PDF]

J Poult Sci, 2021
Nutrition and energy are essential for poultry growth and production performance. Fasting and refeeding have been widely used to study the effects of nutrition, energy, and related mechanisms in chicken. Previous studies have shown that geese have a strong capacity for fat synthesis and storage; thus, changes in the goose liver transcriptome may be ...
Chen Z, Xing Y, Fan X, Liu T, Zhao M, Liu L, Hu X, Cui H, Geng T, Gong D.   +9 more
europepmc   +5 more sources

Bioinformatics and functional experiments reveal that MRC2 inhibits atrial fibrillation via the PPAR signaling pathway. [PDF]

J Thorac Dis, 2023
Atrial fibrillation (AF) is a prevalent cardiac arrhythmia that requires improved clinical markers to increase diagnostic accuracy and provide insight into its pathogenesis. Although some biomarkers are available, new ones need to be discovered to better capture the complex physiology of AF.
Zheng P, Zhang W, Wang J, Gong Q, Xu N, Chen N.   +5 more
europepmc   +3 more sources

LMNB1 regulates breast cancer cell senescence and migration through PPAR signaling pathway. [PDF]

Discov Oncol
Breast cancer is the malignant tumor with the highest incidence in the world. LMNB1 is an important component of the nuclear backbone. LMNB1 is abnormally highly expressed in breast cancer, but its role in tumors still needs to be comprehensively studied.
Meng S, Liu S, Liu C, Yang K, Lai M.
europepmc   +4 more sources

The Interplay between Metabolism, PPAR Signaling Pathway, and Cancer. [PDF]

PPAR Res, 2017
Fanale D, Amodeo V, Caruso S.
europepmc   +6 more sources

Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction [PDF]

PPAR Research, 2020
Peroxisome proliferator-activated receptor (PPAR) group includes three isoforms encoded by PPARG, PPARA, and PPARD genes. High concentrations of PPARs are found in parts of the brain linked to anxiety development, including hippocampus and amygdala. Among three PPAR isoforms, PPARG demonstrates the highest expression in CNS, where it can be found in ...
Olga I. Rudko, Artemii V. Tretiakov, Elena A. Naumova, Eugene A. Klimov   +3 more
openaire   +4 more sources