Results 11 to 20 of about 1,781,780 (142)

Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer [PDF]

Molecular Carcinogenesis, 2020
Because the peroxisome proliferator-activated receptor (PPAR) signaling pathway is involved in development and progression of pancreatic cancer, we investigated associations between genetic variants of the PPAR pathway genes and pancreatic cancer risk by
Hongliang Liu, Xiaowen Liu
exaly   +3 more sources

Acupoint Catgut Embedding Improves Lipid Metabolism in Exercise-Induced Fatigue Rats via the PPAR Signaling Pathway. [PDF]

Animals (Basel), 2023
To improve the phenomenon of exercise-induced fatigue that often occurs during horse racing, we previously studied the improvement in exercise tolerance by acupoint catgut embedding preconditioning in an exercise-induced fatigue rat model.
Song Y, Shi X, Gao Z, Li R, Tian J, Cao X, Yang B, Zhao S, Yang Y.   +8 more
europepmc   +2 more sources

Clinical Relevance and Drug Modulation of PPAR Signaling Pathway in Triple-Negative Breast Cancer: A Comprehensive Analysis. [PDF]

PPAR Res
Triple-negative breast cancer (TNBC) is highly heterogeneous and poses a significant medical challenge due to limited treatment options and poor outcomes.
Zhang Y, Liu Y, Zhang M, Li G, Zhu S, Xie K, Xiao B, Li L.   +7 more
europepmc   +2 more sources

Development and Validation of the Promising PPAR Signaling Pathway-Based Prognostic Prediction Model in Uterine Cervical Cancer. [PDF]

PPAR Res, 2023
A ligand-activated transcription factor, peroxisome proliferator-activated receptor (PPAR) regulates fatty acid uptake and transport. In several studies, upregulation of PPAR expression/activity by cancer cells has been associated with cancer progression.
Zhang Y, Li X, Zhang J, Mao L, Wen Z, Cao M, Mu X.   +6 more
europepmc   +2 more sources

Effects of early florfenicol exposure on glutathione signaling pathway and PPAR signaling pathway in chick liver

Ecotoxicology and Environmental Safety, 2022
Florfenicol (FFC) is a common antibiotic for animals. The nonstandard and excessive use of FFC can cause veterinary drug residues in animals, pollute soil and marine environment, and even threaten human health. Therefore, it is necessary to study the toxicity and side effects of FFC on animals.
Wei Liu, Xiao Wang, Ying Liu, Siyuan Fang, Zhanjun Wu, Chao Han, Wanyu Shi, Yongzhan Bao   +7 more
openaire   +3 more sources

ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway [PDF]

Diabetes, 2020
ETV5 is an ETS transcription factor that has been associated with obesity in genomic association studies. However, little is known about the role of ETV5 in hepatic lipid metabolism and nonalcoholic fatty liver disease. In the current study, we found that ETV5 protein expression was increased in diet- and genetically induced steatotic liver.
Zhuo Mao, Mingji Feng, Zhuoran Li, Minsi Zhou, Langning Xu, Ke Pan, Shaoxiang Wang, Wen Su, Weizhen Zhang   +8 more
openaire   +4 more sources

Crosstalk between the Androgen Receptor and PPAR Gamma Signaling Pathways in the Prostate [PDF]

PPAR Research, 2017
Nuclear receptors are a superfamily of ligand-activated transcription factors that play critical roles in the regulation of normal biological processes and several disease states. Of the nuclear receptors expressed within the prostate, the androgen receptor (AR) promotes the differentiation of prostatic epithelial cells and stimulates production of ...
Emuejevoke Olokpa, Patrice E. Moss, LaMonica V. Stewart   +2 more
openaire   +4 more sources

E2F1-mediated PKMYT1 upregulation promotes prostate cancer progression by inhibiting the PPAR signaling pathway. [PDF]

Sci Rep
Kou Z, Wang Y, Zhu J, Zhu S, Si Z, Zhu H.   +5 more
europepmc   +4 more sources

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo [PDF]

, 2012
We have previously shown that peroxisome proliferator activating receptor ß/d (PPAR ß/d is overexpressed in psoriasis. PPAR ß/d is not present in adult epidermis of mice.
Kevin D. Read (165019), Palmer Colin, Kally Booth, Katrin Hack, Booth Kally, Colin Palmer (165015), Suzanne Norval, Read, Kevin D, Hack Katrin, John Foerster (165047), Robert Kime, Kevin D Read, John Foerster, Kally Booth (165039), Louise Reilly, Suzanne Norval (165024), Read Kevin D., Palmer, Colin; id_orcid, Norval, Suzanne, Reilly, Louise, Louise Reilly (165006), Reilly Louise, Read, Kevin, Palmer, Colin, Hack, Katrin, Robert Kime (165030), Colin Palmer, Kime Robert, Foerster John, Foerster, John, Katrin Hack (165002), Kime, Robert, Norval Suzanne, Booth, Kally   +33 more
core   +1 more source

Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts [PDF]

, 2013
Willin/FRMD6 was first identified in the rat sciatic nerve, which is composed of neurons, Schwann cells, and fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation of the transcriptional coactivator
Tilston-Lünel, A.M., Susan C Barnett, Gunn-Moore Frank J., Tilston-Lunel, Andrew Martin, Moleirinho, S., Jennifer R Higginson, Angus Liselotte, Prystowsky Michael B., Calum Patrick, Liselotte Angus, Andrew M. Tilston-lünel, Michael B. Prystowsky, Patrick, C., Susana Moleirinho, Frank J Gunn-Moore, Moleirinho Susana, Gunn-Moore, Frank J, Gunn-Moore, F.J., Prystowsky, M.B., Moleirinho, Susan, Paul A. Reynolds, Maciej Antkowiak, Susan C. Barnett, Jennifer R. Higginson, Antkowiak Maciej, Barnett Susan C., Paul A Reynolds, Higginson, J.R., Reynolds Paul A., Antkowiak, Maciej, Prystowsky, Michael, Michael B Prystowsky, Barnett, Susan, Antkowiak, M., Reynolds, Paul Andrew, Tilston-Lünel Andrew M., Barnett, S.C., Frank J. Gunn-moore, Angus, Liselotte, Andrew M Tilston-Lünel, Patrick Calum, Patrick, Calum, Higginson Jennifer R., Higginson, JR, Angus, L., Reynolds, P.A.   +45 more
core   +2 more sources