Results 1 to 10 of about 301 (107)

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis. [PDF]

Nat Commun
AbstractInositol pyrophosphates (PP-InsPs) are highly phosphorylated nutrient messengers. The final step of their biosynthesis is catalyzed by diphosphoinositol pentakisphosphate kinase (PPIP5K) enzymes, which are conserved among fungi, plants, and animals. PPIP5Ks contain an N-terminal kinase domain that generates the active messenger 1,5-InsP8and a C-
Raia P, Lee K, Bartsch SM, Rico-Resendiz F, Portugal-Calisto D, Vadas O, Panse VG, Fiedler D, Hothorn M.   +8 more
europepmc   +12 more sources

The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in S. pombe. [PDF]

J Fungi (Basel), 2021
Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by phosphoanhydride bonds. The biological role of this polymer is manifold and diverse and in fungi ranges from cell cycle control, phosphate homeostasis and virulence to post-translational
Pascual-Ortiz M, Walla E, Fleig U, Saiardi A.   +3 more
europepmc   +12 more sources

Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line. [PDF]

Proc Natl Acad Sci U S A, 2021
Significance Central carbon metabolism has the overlapping functions of converting substrate into biomass and the extraction and storage of chemical energy. These metabolic pathways are rewired by cancer cells to selectively support increased biomass demands.
Gu C, Liu J, Liu X, Zhang H, Luo J, Wang H, Locasale JW, Shears SB.   +7 more
europepmc   +7 more sources

Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe. [PDF]

J Fungi (Basel), 2022
Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Kuenzel NA, Alcázar-Román AR, Saiardi A, Bartsch SM, Daunaraviciute S, Fiedler D, Fleig U.   +6 more
europepmc   +7 more sources

The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family. [PDF]

Adv Biol Regul, 2017
The inositol pyrophosphates (diphosphoinositol polyphosphates), which include 1-InsP7, 5-InsP7, and InsP8, are highly 'energetic' signaling molecules that play important roles in many cellular processes, particularly with regards to phosphate and bioenergetic homeostasis. Two classes of kinases synthesize the PP-InsPs: IP6Ks and PPIP5Ks.
Shears SB, Baughman BM, Gu C, Nair VS, Wang H.   +4 more
europepmc   +7 more sources

Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. [PDF]

Chemistry, 2023
How do pyrophosphate analogs compare? The synthesis of a fluorinated analog of an inositol pyrophosphate messenger is reported. Comparison of the physicochemical and biochemical properties of a range of closely related analogs showcases that subtle modifications can distinctly influence the behavior of molecules.
Hostachy S, Wang H, Zong G, Franke K, Riley AM, Schmieder P, Potter BVL, Shears SB, Fiedler D.   +8 more
europepmc   +8 more sources

The Asp1 pyrophosphatase from S. pombe hosts a [2Fe-2S]²⁺ cluster in vivo. [PDF]

J Biol Inorg Chem, 2021
The Schizosaccharomyces pombe Asp1 protein is a bifunctional kinase/pyrophosphatase that belongs to the highly conserved eukaryotic diphosphoinositol pentakisphosphate kinase PPIP5K/Vip1 family.
Rosenbach H, Walla E, Cutsail GE, Birrell JA, Pascual-Ortiz M, DeBeer S, Fleig U, Span I.   +7 more
europepmc   +4 more sources

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis. [PDF]

J Biol Chem, 2017
Proteins responsible for Pi homeostasis are critical for all life. In Saccharomyces cerevisiae, extracellular [Pi] is “sensed” by the inositol-hexakisphosphate kinase (IP6K) that synthesizes the intracellular inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP7) as follows: during a period of Pi starvation, there is a decline
Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB.   +6 more
europepmc   +9 more sources

Crystal Structure and Enzymology of Solanum tuberosum Inositol Tris/Tetrakisphosphate Kinase 1 (StITPK1). [PDF]

Biochemistry, 2023
Inositol phosphates and their pyrophosphorylated derivatives are responsive to the phosphate supply and are agents of phosphate homeostasis and other aspects of physiology. It seems likely that the enzymes that interconvert these signals work against the
Whitfield HL, Rodriguez RF, Shipton ML, Li AWH, Riley AM, Potter BVL, Hemmings AM, Brearley CA.   +7 more
europepmc   +6 more sources

Protein pyrophosphorylation by inositol phosphates: a novel post-translational modification in plants? [PDF]

Front Plant Sci
Inositol pyrophosphates (PP-InsPs) are energy-rich molecules harboring one or more diphosphate moieties. PP-InsPs are found in all eukaryotes evaluated and their functional versatility is reflected in the various cellular events in which they take part ...
Mihiret YE, Schaaf G, Kamleitner M.
europepmc   +3 more sources