Results 11 to 20 of about 301 (107)

The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment [PDF]

The FASEB Journal, 2013
Diphosphoinositol polyphosphates (PP‐InsPs) link nutrient status to the regulation of cellular growth and energy homeostasis; PPInsP turnover may impact bioenergetic diseases such as diabetes. Yet the relationship between PP‐InsP synthesis and cellular bioenergetic health remains unclear.
Jeremy D. Weaver, Huanchen Wang, Stephen B. Shears   +2 more
semanticscholar   +8 more sources

The wheat VIH2-3B, a functional PPIP5K controls the localization of fasciclin-like arabinogalactan protein

bioRxiv
AbstractInositol pyrophosphates (PP[InsPs) are important signalling molecules, that participate in multiple physiological processes across a wide range of eukaryotes. Metabolic pathway kinases (VIP1/VIHs) leading to the production of PP-InsPs are now well characterized in yeast and plants.
Anuj Shukla, Rahul Tanwar, Kanupriya Agrwal, Riya Ghosh, Henning Jacob Jessen, Debabrata Laha, Ajay K Pandey   +6 more
semanticscholar   +3 more sources

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP₇. [PDF]

Biomolecules, 2023
Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code.
Sahu S, Gordon J, Gu C, Sobhany M, Fiedler D, Stanley RE, Shears SB.   +6 more
europepmc   +3 more sources

Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe. [PDF]

Mol Cell Biol, 2018
The generation of two daughter cells with the same genetic information requires error-free chromosome segregation during mitosis. Chromosome transmission fidelity is dependent on spindle structure/function, which requires Asp1 in the fission yeast ...
Pascual-Ortiz M, Saiardi A, Walla E, Jakopec V, Künzel NA, Span I, Vangala A, Fleig U.   +7 more
europepmc   +4 more sources

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase. [PDF]

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Mohanrao R, Manorama R, Ganguli S, Madhusudhanan MC, Bhandari R, Sureshan KM.   +5 more
europepmc   +3 more sources

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis

BMC Biology, 2021
Background Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells.
Anuj Shukla, Mandeep Kaur, Swati Kanwar, Gazaldeep Kaur, Shivani Sharma, Shubhra Ganguli, Vandana Kumari, Koushik Mazumder, Pratima Pandey, Hatem Rouached, Vikas Rishi, Rashna Bhandari, Ajay Kumar Pandey   +12 more
doaj   +2 more sources

Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development. [PDF]

PLoS Genet
Inositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Laurent F, Bartsch SM, Shukla A, Rico-Resendiz F, Couto D, Fuchs C, Nicolet J, Loubéry S, Jessen HJ, Fiedler D, Hothorn M.   +10 more
europepmc   +3 more sources

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. [PDF]

PLoS One, 2016
Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches.
Baughman BM, Wang H, An Y, Kireev D, Stashko MA, Jessen HJ, Pearce KH, Frye SV, Shears SB.   +8 more
europepmc   +3 more sources

Application of CRISPR-Cas9 gene editing technology in basic research, diagnosis and treatment of colon cancer. [PDF]

Front Endocrinol (Lausanne), 2023
Colon cancer is the fourth leading cause of cancer death worldwide, and its progression is accompanied by a complex array of genetic variations. CRISPR/Cas9 can identify new drug-resistant or sensitive mutations in colon cancer, and can use gene editing ...
Meng H, Nan M, Li Y, Ding Y, Yin Y, Zhang M.   +5 more
europepmc   +3 more sources

Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants? [PDF]

Molecules, 2020
The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Cridland C, Gillaspy G.
europepmc   +2 more sources