Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Biological roles of inorganic phosphate require careful regulation of its transport across cell membranes, but mechanisms are poorly understood.
Li X +8 more
europepmc +2 more sources
InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Improved understanding of the epitranscriptomic control process will help decipher regulation of global gene expression. Here, we demonstrate that the cell-signaling inositol pyrophosphate 5-InsP7 stabilizes mRNAs that are normally committed
Sahu S +12 more
europepmc +2 more sources
Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops? [PDF]
Plants (Basel), 2020 Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Freed C, Adepoju O, Gillaspy G.
europepmc +2 more sources
Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals. [PDF]
Molecules, 2020 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Lee S, Kim MG, Ahn H, Kim S.
europepmc +2 more sources
KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype. [PDF]
Proc Natl Acad Sci U S A, 2017 Gu C +7 more
europepmc +2 more sources
Potential therapies targeting nuclear metabolic regulation in cancer
MedComm, Volume 4, Issue 6, December 2023., 2023 1. Cell metabolism and gene control are significantly integrated and regulated by one another. 2. There is a positive feedback loop of metabolism‐epigenetics‐gene regulation which control cancer progression. 3. The discovery of metabolic enzymes and their functions in the nucleus will provide more insights into cancer therapy.
Yanjie Chen +5 more
wiley +1 more source
New Phytologist, Volume 232, Issue 5, Page 2011-2025, December 2021., 2021 Summary Stress and nutrient availability influence cell proliferation through complex intracellular signalling networks. In a previous study it was found that pyro‐inositol polyphosphates (InsP7 and InsP8) produced by VIP1 kinase, and target of rapamycin (TOR) kinase signalling interacted synergistically to control cell growth and lipid metabolism in ...
Inmaculada Couso +5 more
wiley +1 more source
Development of a Virtual Screening Pipeline for the Identification of Small Molecule PPIP5K2 Inhibitors [PDF]
, 2021 Phosphate homeostasis is essential for survival in eucaryotes. It is mediated by inositol phosphates, which are synthesized by a sequence of kinases. One such kinase in humans is diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2).
Leja, Mareike
core +1 more source
The dead phosphatases society: a review of the emerging roles of pseudophosphatases
The FEBS Journal, Volume 287, Issue 19, Page 4198-4220, October 2020., 2020 Phosphatases are signaling enzymes that remove phosphate from proteins, lipids and other cellular components. A significant fraction of the human phosphatases bear mutations in one or several catalytic motifs. These members are referred to as pseudophosphatases and are present in most subfamilies of the phosphatome.
Veronika Reiterer +5 more
wiley +1 more source
Caenorhabditis elegans phosphatase complexes in UniProtKB and Complex Portal
The FEBS Journal, Volume 287, Issue 13, Page 2664-2684, July 2020., 2020 The UniProt Knowledgebase (UniProtKB) and Complex Portal databases facilitate the understanding of how protein phosphorylation is regulated by providing structural and functional information on phosphatase‐containing macromolecular complexes across a wide range of species.
Hema Bye‐A‐Jee +4 more
wiley +1 more source