Results 41 to 50 of about 270,676 (398)
FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]
, 2018 FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang +3 more
core +1 more source
Genome Biology, 2014 Sm-like proteins are highly conserved proteins that form the core of the U6 ribonucleoprotein and function in several mRNA metabolism processes, including pre-mRNA splicing. Despite their wide occurrence in all eukaryotes, little is known about the roles
P. Cui +4 more
semanticscholar +1 more source
G3: Genes, Genomes, Genetics, 2016 Pre-mRNA splicing is an essential component of eukaryotic gene expression and is highly conserved from unicellular yeasts to humans. Here, we present the development and implementation of a sequencing-based reverse genetic screen designed to identify ...
Amy Larson +2 more
doaj +1 more source
Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate
Genes & Development, 2014 Fong et al. examined cotranscriptional pre-mRNA splicing using RNA polymerase II mutants that change average elongation rates genome-wide. Slow and fast elongation affected constitutive and alternative splicing and often both increased or both decreased ...
N. Fong +9 more
semanticscholar +1 more source
Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe [PDF]
, 2010 Nonsense-mediated mRNA decay (NMD) is a translation-linked process that destroys mRNAs with premature translation termination codons (PTCs). In mammalian cells, NMD is also linked to pre-mRNA splicing, usually PTCs trigger strong NMD only when positioned
Carter MS +9 more
core +3 more sources
Regulation of age-dependent expression patterns of five transcription factors in Larix kaempferi
Forestry Research, 2023 To reveal the regulatory mechanisms underlying age-dependent expression patterns, we characterized seven age-related genes, LaDAL1, LaAGL2-2, LaAGL2-3, LaAGL11, LaSOC1-1, LaAP2-1, and LaAP2-2 in terms of transcription and intron splicing in Larix ...
Xiangyi Li +4 more
doaj +1 more source
cis-Acting and trans-acting modulation of equine infectious anemia virus alternative RNA splicing [PDF]
, 2004 Equine infectious anemia virus (EIAV), a lentivirus distantly related to HIV-1, encodes regulatory proteins, EIAV Tat (ETat) and Rev (ERev), from a four-exon mRNA.
Baker, Carl C +3 more
core +1 more source
Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns.
PLoS Biology, 2006 RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of RNA polymerase ...
Martin J Hicks +3 more
doaj +1 more source
Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing [PDF]
, 2002 To examine the involvement of interchromatin granule clusters (IGCs) in transcription and pre-mRNA splicing in mammalian cell nuclei, the serine-arginine (SR) protein kinase cdc2-like kinase (Clk)/STY was used as a tool to manipulate IGC integrity in ...
Sacco-Bubulya, P. A., Spector, D. L.
core +2 more sources
Nucleic Acids Research, 1993 We present a systematic analysis of sequence motifs found in metazoan protein factors involved in constitutive pre-mRNA splicing and in alternative splicing regulation.
E. Birney, Sanjay Kumar, A. Krainer
semanticscholar +1 more source