Results 101 to 110 of about 924,617 (340)

Enhancing Cold Adaptation of Bidomain Amylases by High‐Throughput Computational Engineering

Angewandte Chemie, EarlyView.
This work uncovers molecular determinants of cold adaptation in bidomain amylases by combining MD simulations and biochemical assays, revealing that increased domain separation drives enhanced activity at low temperatures. Guided by this principle, high‐throughput in silico linker screening of mesophilic psA was performed, yielding variant psA121 with ...
Ning Ding, Yaoyukun Jiang, Robbie Ge, Qianzhen Shao, Wook Shin, Xinchun Ran, Zhongyue J. Yang   +6 more
wiley   +2 more sources

Chemical Diversity of Metal Sulfide Minerals and Its Implications for the Origin of Life

Life, 2018
Prebiotic organic synthesis catalyzed by Earth-abundant metal sulfides is a key process for understanding the evolution of biochemistry from inorganic molecules, yet the catalytic functions of sulfides have remained poorly explored in the context of the ...
Yamei Li, Norio Kitadai, Ryuhei Nakamura
doaj   +1 more source

Toward homochiral protocells in noncatalytic peptide systems

, 2009
The activation-polymerization-epimerization-depolymerization (APED) model of Plasson et al. has recently been proposed as a mechanism for the evolution of homochirality on prebiotic Earth.
A Brack, A Brandenburg, A Brandenburg, A Commeyras, A Lazcano, B-M Rode, C Shen, C Viedma, CJ Welch, D Castelvecchi, D Deamer, D Deamer, D Deamer, D Segrè, D-G Blackmond, D-K Kondepudi, F-C Frank, G Wächtershäuser, G-F Joyce, G-F Joyce, H-J Morowitz, J-A Wattis, J-D Gunton, J-S Langer, J-W Szostak, JD Dunitz, K Soai, L Leman, M Fishkis, M Gleiser, M Gleiser, M Gleiser, M Huber, M Huber, M Reches, M Reches, M-P Robertson, Marcelo Gleiser, N Berclaz, N Berclaz, P-A Monnard, P-G-H Sandars, R Cotterill, R Lathe, R Lathe, R Plasson, R-M Smith, R-P Bywater, S Fox, S Fox, S Fox, S Lonchin, S Rasmussen, S Santoso, S Vauthey, S-L Miller, Sara Imari Walker, UJ Meierhenrich, V-A Avetisov, W-A Bonner, Y Saito, Y Saito   +61 more
core   +1 more source

The Influence of Galactic Cosmic Rays on Ion-Neutral Hydrocarbon Chemistry in the Upper Atmospheres of Free-Floating Exoplanets [PDF]

, 1989
Cosmic rays may be linked to the formation of volatiles necessary for prebiotic chemistry. We explore the effect of cosmic rays in a hydrogen-dominated atmosphere, as a proof-of-concept that ion-neutral chemistry may be important for modelling hydrogen ...
C. Bilger, Ch. Helling, Miller, P. B. Rimmer, Rimmer, Skilling   +5 more
core   +3 more sources

Resilient Membranized Coacervates Formed through Spontaneous Wrapping of Heat‐Destabilized Lipid Bilayers around Coacervate Droplets

Advanced Science, EarlyView.
We present a universal way to wrap liposomes around coacervate droplets. Membrane‐enclosed coacervates form when heat‐destabilized liposomes are mixed with coacervates. Membranized coacervates (MCs) can survive pH and ionic strength fluctuations, osmotic stress, and low temperatures.
Sadaf Javed, Evan Spruijt
wiley   +1 more source

The Prevailing Catalytic Role of Meteorites in Formamide Prebiotic Processes

Life, 2018
Meteorites are consensually considered to be involved in the origin of life on this Planet for several functions and at different levels: (i) as providers of impact energy during their passage through the atmosphere; (ii) as agents of geodynamics ...
Raffaele Saladino, Lorenzo Botta, Ernesto Di Mauro   +2 more
doaj   +1 more source

Chiral Polymerization in Open Systems From Chiral-Selective Reaction Rates

, 2012
We investigate the possibility that prebiotic homochirality can be achieved exclusively through chiral-selective reaction rate parameters without any other explicit mechanism for chiral bias.
A Bakasov, A Salam, Bradley J. Nelson, C Chyba, C McKay, D Fitz, DG Fraser, DK Kondepudi, DP Glavin, F Frank, FHC Crick, J Bailey, JAD Wattis, JAD Wattis, JB Corliss, JD Dunitz, JR Cronin, LD Landau, LE Orgel, M Gleiser, M Gleiser, MA Zuilen van, Marcelo Gleiser, PC Joshi, PCW Davies, PCW Davies, PGH Sandars, R Gomes, R Hazen, R Plasson, SA Benner, Sara Imari Walker, SJ Mojzsis, W Gilbert, WA Bonner, Y Saito, Y Yamagata, Z Martins   +37 more
core   +1 more source

Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics

Advanced Science, EarlyView.
Intestinal barrier stability is vital for gut health. Plastic polyethylene terephthalate (PET) disrupts this barrier, causing inflammation and infections. This study encodes transforming growth factor‐β into EcN and modifies its surface with pH‐responsive polymer (EcNT@L), creating an oral drug delivery system to repair nano PET‐induced intestinal ...
Wenxin Chen, Qiyan Guo, Hong Li, Xue Chi, Xiang Ma, Yanqiong Tang, Quanfeng Liang, Zhu Liu, Yong Liu, Juanjuan Li   +9 more
wiley   +1 more source

Inulin‐type fructans and short‐chain fructooligosaccharides—their role within the food industry as fat and sugar replacers and texture modifiers—what needs to be considered!

Food Science &Nutrition, Volume 11, Issue 1, Page 17-38, January 2023., 2023
Inulin‐type fructans and short‐chain fructooligosaccharides are becoming and increasingly common ingredient used in the food industry as fat and sugar replacers and texture modifiers. Yet careful consideration must be given to the type and quantity of fructans used in replacement of fat and sugar in order product integrity while maintaining product ...
Peter Philip James Jackson, Anisha Wijeyesekera, Robert Adrian Rastall   +2 more
wiley   +1 more source

Prebiotic chemistry: A fuzzy field

Comptes Rendus. Chimie, 2010
If prebiotic chemistry is defined as the study of the chemical steps, which lead to the first organisms, a clear-cut definition of “living organism” is needed. Unfortunately, no unambiguous and universally accepted definition exists for the concept “living”.
Bruylants, Gilles, Bartik, Kristin, Reisse, Jacques   +2 more
openaire   +2 more sources