Results 11 to 20 of about 31,350 (256)

Understanding pregabalin misuse and dependence: Insights from a North Indian addiction treatment center

Indian Journal of Psychiatry
Background: Pregabalin, approved for various medical conditions, has shown increasing misuse potential globally. However, limited research exists on pregabalin dependence in India.
Abhishek Ghosh, Shantanu Shukla, Mondeep Dhankar, Shalini S. Naik, BN Subodh, Debasish Basu   +5 more
doaj   +2 more sources

The preemptive effects of oral pregabalin on perioperative pain management in lower limb orthopedic surgery: a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research, 2022
Background To systematically review the literature and provide a comprehensive understanding of the preemptive effects of oral pregabalin on perioperative pain management in lower limb orthopedic surgery. Method We searched three electronic databases for
Zhao Chen, Jialei Chen, Rong Luo, Jiabao Jiang, Zhou Xiang   +4 more
doaj   +2 more sources

Pregabalin prescribing patterns in Australian general practice, 2012–2018: a cross-sectional study

BJGP Open, 2021
Background: In 2013 pregabalin was subsidised by Australia’s Pharmaceutical Benefits Scheme (PBS) for neuropathic pain. Since the subsidy, pregabalin prescribing has been increasing in Australia and so has related harm.
Andrea L Schaffer, Doreen Busingye, Kendal Chidwick, Jonathan Brett, Suzanne Blogg   +4 more
doaj   +2 more sources

Prenatal exposure to pregabalin, birth outcomes and neurodevelopment – a population-based cohort study in four Nordic countries

Drug Safety, 2023
Pregabalin is an antiepileptic drug frequently prescribed to pregnant women. Risks of adverse birth and postnatal neurodevelopmental outcomes following prenatal exposure to pregabalin are uncertain.
E. Dudukina, S. Szépligeti, P. Karlsson, K. Asomaning, A. Daltveit, K. Hakkarainen, F. Hoti, H. Kieler, Astrid Lunde, I. Odsbu, Matti Rantanen, J. Reutfors, Laura Saarelainen, V. Ehrenstein, G. Toft   +14 more
semanticscholar   +1 more source

Different Gabapentin and Pregabalin Dosages for Perioperative Pain Control in Patients Undergoing Spine Surgery

JAMA Network Open, 2023
Key Points Question What is the association of different dosages of pregabalin and gabapentinoids with pain control and adverse outcomes in patients undergoing spine surgery?
S. H. L. Tsai, Ching-Wei Hu, Sally El Sammak, Sulaman Durrani, A. Ghaith, Che Chung Justin Lin, E. Z. Krzyż, M. Bydon, T. Fu, Tung-Yi Lin   +9 more
semanticscholar   +1 more source

Misuse of Pregabalin: a qualitative study from a patient’s perspective

BMC Public Health, 2023
Introduction The misuse of Pregabalin has been the subject of growing concern for several years. The effects sought are multiple and it is rarely taken as a single drug.
L. Servais, Vincent Huberland, L. Richelle   +2 more
semanticscholar   +1 more source

Pregabalin inhibits purinergic P2Y2 receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain.

European Journal of Pharmacology, 2023
BACKGROUNDS Transient receptor potential vanilloid 4 (TRPV4)-mediated astrocyte activation is critical to neuropathic pain. Pregabalin, a widely used drug to treat chronic pain, is reported to lower the intracellular calcium level. However, the molecular
Shasha Song, Qianwen Wang, Yujuan Qu, Wenshuang Gao, Danyang Li, Xiaoqian Xu, Shouwei Yue   +6 more
semanticscholar   +1 more source

The association between Gabapentin or Pregabalin use and the risk of dementia: an analysis of the National Health Insurance Research Database in Taiwan

Frontiers in Pharmacology, 2023
Objective: Previous studies have shown that gabapentin or pregabalin use is associated with cognitive decline. Herein, we aimed to evaluate the association between gabapentin or pregabalin use and the risk of dementia.
Yu-Hua Huang, Mei-Hung Pan, Hwai I. Yang
semanticscholar   +1 more source

Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury

Journal of Neuroinflammation, 2022
Background Radiation-induced brain injury (RIBI) is the most serious complication of radiotherapy in patients with head and neck tumors, which seriously affects the quality of life.
Zhan Zhang, Jingru Jiang, Yong He, Jinhua Cai, Jiatian Xie, Min-Yi Wu, Mengdan Xing, Zhenzhen Zhang, Haocai Chang, Pei Yu, Siqi Chen, Yuhua Yang, Zhongshan Shi, Qiang Liu, Haohui Sun, Baixuan He, Junbo Zeng, Jialin Huang, Jiongxue Chen, Honghong Li, Yi Li, Wei-Jye Lin, Yamei Tang   +22 more
semanticscholar   +1 more source

Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy

Cardiovascular Diabetology, 2022
Background Gabapentin and pregabalin are commonly prescribed medications to treat pain in patients with diabetic neuropathy. Gabapentin and pregabalin can cause fluid retention, which is hypothesized to be associated with cardiovascular diseases. However,
Yiheng Pan, P. Davis, David C. Kaebler, R. P. Blankfield, Rong Xu   +4 more
semanticscholar   +1 more source