Results 21 to 30 of about 38,319 (245)

Sleep Dysfunction in Fibromyalgia and Therapeutic Approach Options [PDF]

open access: yes, 2020
Fibromyalgia, characterised by persistent pain, sleep disturbance, fatigue and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis.
Lawson, Kim
core   +1 more source

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

open access: yes, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe   +10 more
core   +1 more source

Analgesic effectiveness and tolerability of oral oxycodone/naloxone and pregabalin in patients with lung cancer and neuropathic pain. An observational analysis [PDF]

open access: yes, 2016
INTRODUCTION: Cancer-related pain has a severe negative impact on quality of life. Combination analgesic therapy with oxycodone and pregabalin is effective for treating neuropathic cancer pain.
Borghesi, Cristina   +6 more
core   +2 more sources

Suicidal ideation and behavior among subjects with substance abuse disorder related to pregabalin

open access: yesMiddle East Current Psychiatry, 2022
Background Although pregabalin abuse is increasing worldwide and may be associated with increased suicidal ideation and behavior, few studies were done in Egypt searching for the effect of pregabalin on suicide.
Abdallah Saad Ibrahim   +4 more
doaj   +1 more source

The Effect of Pregabalin on the Minimum Alveolar Concentration of Sevoflurane: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial

open access: yesFrontiers in Medicine, 2022
BackgroundPregabalin is commonly used perioperatively to reduce post-operative pain and opioid consumption and to prevent the development of chronic pain.
Johannes Müller   +5 more
doaj   +1 more source

Topical treatment of peripheral neuropathic pain: applying the evidence [PDF]

open access: yes, 2017
Patients with peripheral neuropathic pain (NP) may only achieve partial pain relief with currently recommended first-line oral treatments, which are also associated with systemic adverse events.
Cruccu, Giorgio, Sommer, Claudia
core   +1 more source

A meta-analysis of pharmacotherapy for social anxiety disorder: an examination of efficacy, moderators, and mediators [PDF]

open access: yes, 2017
INTRODUCTION: Social anxiety disorder (SAD) is among the most prevalent mental disorders, associated with impaired functioning and poor quality of life. Pharmacotherapy is the most widely utilized treatment option.
Borenstein M   +8 more
core   +2 more sources

Pregabalin for Postoperative pain in patients undergoing spinal surgery: A Dose ranging randomized clinical study

open access: yesМедицина болю, 2023
Background: The efficacy of pregabalin in acute post-surgical pain management is well demonstrated. As, the use of pregabalin is officially not approved and hence, there is no dosing guideline as well.
Palak Goel   +5 more
doaj   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

open access: yesAngewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis   +2 more
wiley   +2 more sources

The preemptive effects of oral pregabalin on perioperative pain management in lower limb orthopedic surgery: a systematic review and meta-analysis

open access: yesJournal of Orthopaedic Surgery and Research, 2022
Background To systematically review the literature and provide a comprehensive understanding of the preemptive effects of oral pregabalin on perioperative pain management in lower limb orthopedic surgery. Method We searched three electronic databases for
Zhao Chen   +4 more
doaj   +1 more source

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