Results 31 to 40 of about 26,979 (243)

Nanoemulsion formulation of pregabalin for enhanced nose to brain delivery and biological tracking using radiolabeling with 99mTc

Bulletin of Faculty of Pharmacy Cairo University
Pregabalin is a γ-aminobutyric acid analogue used for the treatment of neuropathic pain, seizures, and anxiety disorders. After oral administration, its level of brain penetration is rather modest. In this research, pregabalin was formulated successfully
Hend Fayez, Adli A. Selim, Rehab N. Shamma, Hassan M. Rashed   +3 more
doaj   +1 more source

Generic pregabalin : current situation and implications for health authorities, generics and biosimilars manufacturers in the future [PDF]

, 2015
The manufacturer of pregabalin has a second use patent covering prescribing for neuropathic pain: its principal indication. The manufacturer has threatened legal action in the UK if generic pregabalin rather than Lyrica is prescribed for this indication.
Fogele, Antra, Langner, Irene, Laius, Ott, Magnusson, Einar, Vitry, Agnes, Slabý, Juraj, Tomek, Dominik, Garuoliene, Kristina, Jayathissa, Sisira, Zara, Corinne, Bryson, Scott, Godman, Brian, Skiold, Peter, Fusté, Anna Coma, Schiffers, Krijn, Martin, Andrew, Herholz, Harald, Karlsson, Eva Andersén, Piessnegger, Jutta, Viksna, Anita, Bochenek, Tomasz, D’Agata, Marco, Metcalfe, Scott, Kwon, Hye-Young, de Bruyn, Winne, Bak Pedersen, Hanne, Sermet, Catherine, Fraeyman, Jessica, Markovic-Pekovic, Vanda, Selke, Gisbert W., Baumgärtel, Christoph, McTaggart, Stuart, Kalaba, Marija, Fürst, Jurij, Ringerud, Anne Marthe, Wilcock, Michael, Sović-Brkičić, Ljiljana, Hoffmann, Mikael, Malmström, Rickard E   +38 more
core   +3 more sources

Pregabalin dispensing patterns in Amman-Jordan: An observational study from community pharmacies

Saudi Pharmaceutical Journal, 2018
Objectives: Pregabalin is currently approved for the treatment of epilepsy, generalized anxiety disorder, neuropathic pain and fibromyalgia. Rising attention to the abuse liability of pregabalin causing addictive behaviors is partially based on case ...
Amneh Al-Husseini, Rana Abu-Farha, Mayyada Wazaify, Marie Claire Van Hout   +3 more
doaj   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

Advanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko, Eric S. Larsen, Govind Paneru, Kisung Lee, Diana V. Kolygina, Yankai Jia, Elizabeth Maria Clarissa, Wai‐Shing Wong, Bartosz A. Grzybowski   +8 more
wiley   +1 more source

Pregabalin use in forensic hospitals and prisons in German speaking countries—a survey study of physicians

Frontiers in Public Health
BackgroundPregabalin is a gamma-aminobutyric acid (GABA) analog that was approved in the EU in 2004 for the treatment of neuropathic pain, generalized anxiety disorder and epilepsy.
Michal Novotny, Michal Novotny, Jan Bulla, Daniela Hubl, Sebastian Karl Maximilian Fischer, Martin Grosshans, Andreas Gutzeit, Andreas Gutzeit, Andreas Gutzeit, Oliver Bilke-Hentsch, Erich Seifritz, Jochen Mutschler   +11 more
doaj   +1 more source

Involvement of the dopaminergic system in the reward-related behavior of pregabalin

Scientific Reports, 2021
There has been an increase in cases of drug addiction and prescription drug abuse worldwide. Recently, pregabalin abuse has been a focus for many healthcare agencies, as highlighted by epidemiological studies.
Yusuf S. Althobaiti, Farooq M. Almutairi, Fahad S. Alshehri, Ebtehal Altowairqi, Aliyah M. Marghalani, Amal A. Alghorabi, Walaa F. Alsanie, Ahmed Gaber, Hashem O. Alsaab, Atiah H. Almalki, Alqassem Y. Hakami, Turki Alkhalifa, Ahmad D. Almalki, Ana M. G. Hardy, Zahoor A. Shah   +14 more
doaj   +1 more source

Pregabalin prescribing patterns in Australian general practice, 2012–2018: a cross-sectional study

BJGP Open, 2021
Background: In 2013 pregabalin was subsidised by Australia’s Pharmaceutical Benefits Scheme (PBS) for neuropathic pain. Since the subsidy, pregabalin prescribing has been increasing in Australia and so has related harm.
Andrea L Schaffer, Doreen Busingye, Kendal Chidwick, Jonathan Brett, Suzanne Blogg   +4 more
doaj   +1 more source

Preoperative Risk Factors for Opioid Use Predict Self‐Reported Health and Function Up to 6 Months After Anterior Cruciate Ligament Reconstruction

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To identify risk factors that predict the need for rescue opioid use and patient‐reported outcomes following an opioid‐limiting postoperative analgesia protocol after anterior cruciate ligament reconstruction. Methods This prospective cohort study recruited 44 patients undergoing primary arthroscopic‐assisted anterior cruciate ligament ...
Eric V. Neufeld, William DeGouveia, Camille Pinpin, Matthew Zinner, Michael J. Sayegh, Michael J. Meade, Steven E. Rokito   +6 more
wiley   +1 more source