Results 41 to 50 of about 26,979 (243)

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Understanding pregabalin misuse and dependence: Insights from a North Indian addiction treatment center

Indian Journal of Psychiatry
Background: Pregabalin, approved for various medical conditions, has shown increasing misuse potential globally. However, limited research exists on pregabalin dependence in India.
Abhishek Ghosh, Shantanu Shukla, Mondeep Dhankar, Shalini S. Naik, BN Subodh, Debasish Basu   +5 more
doaj   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT

Health Technology Assessment, 2022
Background: The mainstay of treatment for diabetic peripheral neuropathic pain is pharmacotherapy, but the current National Institute for Health and Care Excellence guideline is not based on robust evidence, as the treatments and their combinations have ...
Solomon Tesfaye, Gordon Sloan, Jennifer Petrie, David White, Mike Bradburn, Tracey Young, Satyan Rajbhandari, Sanjeev Sharma, Gerry Rayman, Ravikanth Gouni, Uazman Alam, Steven A Julious, Cindy Cooper, Amanda Loban, Katie Sutherland, Rachel Glover, Simon Waterhouse, Emily Turton, Michelle Horspool, Rajiv Gandhi, Deirdre Maguire, Edward Jude, Syed Haris Ahmed, Prashanth Vas, Christian Hariman, Claire McDougall, Marion Devers, Vasileios Tsatlidis, Martin Johnson, Didier Bouhassira, David L Bennett, Dinesh Selvarajah   +31 more
doaj   +1 more source

Attenuation of hemodynamic response to laryngoscopy and tracheal intubation in adult patients using 75 mg and 150 mg of oral pregabalin: A dose-response study in a tertiary care hospital, Telangana, India

Asian Journal of Medical Sciences, 2023
Background: Laryngoscopy and tracheal intubation can cause a significant hemodynamic response, leading to adverse events. Pregabalin is a relatively new drug used to attenuate this response. Aims and Objectives: The aim of this study is to compare the
Srinivas Naik Bhukya , Thati Nagendar , Mounika Vadithya , Sindhuja K   +3 more
doaj   +1 more source

Chiari I Malformation: Review and Update of Current Treatment Options

Clinical Anatomy, EarlyView.
ABSTRACT The pathophysiology of Chiari malformation type I (CM‐I) is complex, involving structural abnormalities at the craniovertebral junction that result in herniation of the cerebellar tonsils through the foramen magnum. In this study, we aim to present and evaluate current treatment options for CM‐I, with a focus on evidence‐based clinical ...
Jordan J. Lo, Shuhei Shiino, Stephen Z. Shapiro, Brianna L. Hines, Noritaka Komune, Carmine Antonio Donofrio, Filippo Badaloni, Antonio Fioravanti, Joseph Lockwood, C. J. Bui, Aaron S. Dumont, R. Shane Tubbs   +11 more
wiley   +1 more source

A comparative study of intravenous fentanyl, oral pregabalin, and a combination of both for attenuation of hemodynamic response to laryngoscopy and tracheal intubation

MRIMS Journal of Health Sciences
Background Responses due to laryngoscopy and endotracheal intubation have an effect on blood pressure, heart rate, catecholamines, and oxygen demand of myocardium. These transient changes may affect those with known cardiovascular disease.
Sarayu Ramamurthy, Guruprasad Bettaswamy
doaj   +1 more source

Pregabalin abuse among patients with opioid use disorders may increase the severity of withdrawal symptoms: a single-center, case-control study

Psychiatry and Clinical Psychopharmacology, 2019
OBJECTIVE: Opioid addiction is a disease that is increasing in our country, Turkey, and around the world, which it is difficult to treat in medical, social, and economic terms.
Özlem Çıtak Ekici, Volkan Şahiner, Gamze Erzin, Davut Ocak, Şafak Yalçın Şahiner, Erol Göka   +5 more
doaj   +1 more source

Prevalence and risk factors of pregabalin misuse among patients with substance use disorder

Al-Azhar Assiut Medical Journal, 2019
Background Pregabalin use disorder is an alarming phenomenon demonstrated in many countries. Some countries classified it as a class C controlled substance in a schedule V controlled substance.
Amgad A.M Gabr
doaj   +1 more source

A Selectfluor‐based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications

Chemistry – A European Journal, EarlyView.
Starting from carboxylic acids and Selectfluor‐derivatives, functionalized diazabicyclooctanes can be obtained via a novel Polonovski‐type rearrangement proceeding under mild reaction conditions. Besides their use in organic synthesis the unique structure and reactivity of the rearrangement products enables applications in medicinal chemistry ...
Jakob Kuhn, Susanne Gradl, Vanessa Osterloh, Peter Gmeiner, Harald Hübner, Markus R. Heinrich   +5 more
wiley   +1 more source