Results 51 to 60 of about 18,065 (250)
SPA70 is a potent antagonist of human pregnane X receptor
Nature Communications, 2017 The xenobiotic-activated human pregnane X receptor (hPXR) regulates drug metabolism. Here the authors develop hPXR modulators, which are of potential therapeutic interest and functionally and structurally characterize the antagonist SPA70 and the ...
Wenwei Lin +9 more
doaj +1 more source
Targeting the pregnane X receptor in liver injury [PDF]
Expert Opinion on Therapeutic Targets, 2012 The nuclear receptor pregnane X receptor (PXR) is a well-characterized hepatic xenobiotic sensor whose activation by chemically diverse compounds results in the induction of drug clearance pathways that rid the body of potentially toxic substances, thus conferring protection from foreign chemicals and endobiotics.PXR activities are implicated in drug ...
Tao, Li +5 more
openaire +2 more sources
Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor
Journal of Pharmacological Sciences, 2014 .: The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is activated by a number of clinically prescribed drugs and herbal extracts.
Rongrong Deng +10 more
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CYP3A4 and pregnane X receptor humanized mice [PDF]
Journal of Biochemical and Molecular Toxicology, 2007 AbstractMarked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450‐ and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (BAC) and P1 phage artificial chromosomes (PAC) genomic ...
openaire +2 more sources
Journal of Pharmacy & Pharmaceutical Sciences, 2012 Purpose. Intestinal ischemia-reperfusion (I/R) damages remote organs, including the liver, and promotes multi-organ failure (MOF). However, the molecular mechanisms underlying acute liver injury after intestinal I/R have not been completely elucidated ...
Jiro Ogura +13 more
doaj +1 more source
Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity
Pharmacological ResearchMetabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie +4 more
doaj +1 more source
PLoS ONE, 2014 The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics.
Marianne Mathäs +6 more
doaj +1 more source
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]
, 2015 Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu +3 more
core +1 more source
Marine Drugs, 2018 Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10),
Zhong-Ping Jiang +6 more
doaj +1 more source
Cells, 2022 Plastic-associated endocrine disrupting chemicals (EDCs) have been implicated in the etiology of cardiovascular disease (CVD) in humans, but the underlying mechanisms remain elusive.
Jingwei Liu +5 more
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