Results 51 to 60 of about 16,876 (211)
Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features [PDF]
, 2015 Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of ...
Bergamasco B +14 more
core +2 more sources
CYP3A4 and pregnane X receptor humanized mice [PDF]
Journal of Biochemical and Molecular Toxicology, 2007 AbstractMarked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450‐ and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (BAC) and P1 phage artificial chromosomes (PAC) genomic ...
openaire +2 more sources
Role of pregnane X receptor in chemotherapeutic treatment [PDF]
Cancer Chemotherapy and Pharmacology, 2014 Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that differently expresses not only in human normal tissues but also in numerous types of human cancers. PXR can be activated by many endogenous substances and exogenous chemicals, and thus affects chemotherapeutic effects and intervenes drug-drug interactions by regulating its ...
Wei, Zhuo +5 more
openaire +2 more sources
Journal of Pharmacy & Pharmaceutical Sciences, 2012 Purpose. Intestinal ischemia-reperfusion (I/R) damages remote organs, including the liver, and promotes multi-organ failure (MOF). However, the molecular mechanisms underlying acute liver injury after intestinal I/R have not been completely elucidated ...
Jiro Ogura +13 more
doaj +1 more source
Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity
Pharmacological ResearchMetabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie +4 more
doaj +1 more source
PLoS ONE, 2014 The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics.
Marianne Mathäs +6 more
doaj +1 more source
Marine Drugs, 2018 Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10),
Zhong-Ping Jiang +6 more
doaj +1 more source
Independent elaboration of steroid hormone signaling pathways in Metazoans [PDF]
, 2009 Steroid hormones regulate many physiological processes in vertebrates, nematodes and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors.
Gabriel V. Markov +5 more
core +3 more sources
Synthetic epoxy-pregnan steroids: effects on anxiety behavior in rats [PDF]
, 2016 Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like ...
Coirini, Hector +2 more
core +1 more source
Cells, 2022 Plastic-associated endocrine disrupting chemicals (EDCs) have been implicated in the etiology of cardiovascular disease (CVD) in humans, but the underlying mechanisms remain elusive.
Jingwei Liu +5 more
doaj +1 more source