Results 71 to 80 of about 18,065 (250)

Polymorphisms in NF-kappa B, PXR, LXR, PPAR gamma and risk of inflammatory bowel disease [PDF]

, 2011
AIM: To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease (IBD). METHODS: Genotypes of nuclear factor (NF)-kappa B (NFKB1) NF kappa B -94ins/del (rs28362491); peroxisome proliferator-activated ...
Andersen, Vibeke, Christensen, Jane, Ernst, Anja, Jacobsen, Bent A., Krarup, Henrik B., Tjonneland, Anne, Vogel, Ulla Birgitte   +6 more
core   +2 more sources

Bile Acids as Key Mediators of the Gut Microbiota–Immune Axis: Potential Biomarker and Therapeutic Perspectives

BioFactors, Volume 52, Issue 1, January/February 2026.
Primary bile acids synthesized in the liver are transformed by gut microbes into secondary bile acids that engage receptors such as FXR and TGR5, thereby modulating immune function and metabolic homeostasis. Dysregulation of these signaling pathways contributes to MASH, NAFLD, IBD, and neurodegenerative disorders, underscoring their relevance as ...
Simone Baldi, Margherita Turrini, Francesco Cei, Marta Menicatti, Gianluca Bartolucci, Amedeo Amedei   +5 more
wiley   +1 more source

Regulation of biotransformation systems and ABC transporters by Benznidazole in HepG2 cells: involvement of Pregnane X-Receptor [PDF]

, 2012
Background: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet.
Arias, Agostina, Catania, Viviana Alicia, Luquita, Marcelo Gabriel, Mottino, Aldo Domingo, Perdomo, Virginia, Rigalli, Juan Pablo, Ruiz, Maria Laura, Theile, Dirk, Villanueva, Silvina Stella Maris, Weiss, Johanna   +9 more
core   +2 more sources

Cholesterol detoxification by the nuclear pregnane X receptor [PDF]

Proceedings of the National Academy of Sciences, 2005
We have a love–hate relationship with cholesterol. On one hand, cholesterol is an essential component of cell membranes and serves as the precursor to steroid hormones and bile acids. On the other hand, cholesterol can clog blood vessels and give rise to cardiovascular disease.
openaire   +2 more sources

Glucomannan from Dendrobium officinale Alleviates Colitis via Modulating Gut Microbiota and Upregulating Deoxycholic Acid Production

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dietary fiber is a bioactive substance that can modulate gut microbiota and exert a relieving effect on inflammatory bowel disease (IBD). Dendrobium officinale polysaccharide (DOP) is a type of bioactive dietary fiber that has been proven to have various biological activities on intestinal function.
Jie Xu, Shanshan Zhang, Qi Chen, Chenqing Xu, Siying Wu, Qiongni Lin, Zhipeng Li, Qixing Nie   +7 more
wiley   +1 more source

Nuclear Receptors as Targets for Drug Development: Regulation of Cholesterol and Bile Acid Metabolism by Nuclear Receptors

Journal of Pharmacological Sciences, 2005
Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
doaj   +1 more source

Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice. [PDF]

, 2020
BACKGROUND:Polychlorinated biphenyls (PCBs) are environmental toxicants; PCB exposure has been associated with adverse effects on wildlife and humans. However, the mechanisms underlying these adverse effects are not fully understood.
Ambrosio, Maria Elena, Blumberg, Bruce, Egusquiza, Riann Jenay, Kay, Kaelen Marie, Lehmler, Hans-Joachim, Wang, Shuyi Gin, Zhang, Chunyun   +6 more
core  

Rifaximin improves Clostridium difficile toxin A-induced toxicity in Caco-2 cells by the PXR-dependent TLR4/MyD88 /NF-?B pathway [PDF]

, 2016
Background: Clostridium difficile infections (CDIs) caused by Clostridium difficile toxin A (TcdA) lead to severe ulceration, inflammation and bleeding of the colon, and are difficult to treat.
BRUZZESE, EUGENIA, Capoccia, Elena, CUOMO, ROSARIO, D'ALESSANDRO, ALESSANDRA, Esposito, Giuseppe, Gigli, Stefano, Nobile, Nicola, PESCE, MARCELLA, SARNELLI, GIOVANNI, Seguella, Luisa, Steardo, Luca   +10 more
core   +3 more sources

Anti‐Tubercular Drug‐Induced Liver Injury: Current Understanding and Emerging Directions

JGH Open, Volume 10, Issue 1, January 2026.
ABSTRACT Most common adverse effect causing cessation of anti‐tubercular treatment (ATT) is drug‐induced liver injury (DILI) which is unpredictable due to its idiosyncratic nature. ATT is the most common cause of DILI and drug‐induced acute liver failure (ALF) in South East Asia.
Shubham Prasad, Himanshu Narang, Saurabh Kedia, Vineet Ahuja   +3 more
wiley   +1 more source

Regulation of bile acid receptor activity

Liver Research, 2018
Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 ...
Yu-Jui Yvonne Wan, Lili Sheng
doaj   +1 more source