Results 71 to 80 of about 16,876 (211)

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells

STAR Protocols, 2021
Summary: Here, we describe an optimized protocol to identify specific nuclear receptor ligands. First, to rule out any compound interference with luciferase activity per se, we describe an in vitro assay assessing potential inhibition or activation of ...
Alexandre Berthier, Bart Staels, Philippe Lefebvre   +2 more
doaj   +1 more source

Deficiency of Capicua disrupts bile acid homeostasis [PDF]

, 2018
Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown.
Choi, N, Fryer, JD, Hwang, D, Jung, HY, Kang, H, Kim, E, KIM, KYONG TAI, Kim, S, Lee, J, LEE, YOONTAE, Park, S, Yoe, J, Zoghbi, HY   +12 more
core   +2 more sources

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source

Cholesterol detoxification by the nuclear pregnane X receptor [PDF]

Proceedings of the National Academy of Sciences, 2005
We have a love–hate relationship with cholesterol. On one hand, cholesterol is an essential component of cell membranes and serves as the precursor to steroid hormones and bile acids. On the other hand, cholesterol can clog blood vessels and give rise to cardiovascular disease.
openaire   +2 more sources

Nuclear Receptors as Targets for Drug Development: Regulation of Cholesterol and Bile Acid Metabolism by Nuclear Receptors

Journal of Pharmacological Sciences, 2005
Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
doaj   +1 more source

Regulation of biotransformation systems and ABC transporters by Benznidazole in HepG2 cells: involvement of Pregnane X-Receptor [PDF]

, 2012
Background: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet.
Arias, Agostina, Catania, Viviana Alicia, Luquita, Marcelo Gabriel, Mottino, Aldo Domingo, Perdomo, Virginia, Rigalli, Juan Pablo, Ruiz, Maria Laura, Theile, Dirk, Villanueva, Silvina Stella Maris, Weiss, Johanna   +9 more
core   +2 more sources

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.

PLoS ONE, 2015
Steroid and xenobiotic receptor (SXR) and its murine ortholog, pregnane X receptor (PXR), are nuclear receptors that are expressed at high levels in the liver and the intestine where they function as xenobiotic sensors that induce expression of genes ...
Kotaro Azuma, Stephanie C Casey, Tomohiko Urano, Kuniko Horie-Inoue, Yasuyoshi Ouchi, Bruce Blumberg, Satoshi Inoue   +6 more
doaj   +1 more source