Results 91 to 100 of about 6,716 (130)
Some of the next articles are maybe not open access.
ACS Medicinal Chemistry Letters, 2021
The pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, phase II enzymes, and multidrug efflux pumps. Therefore, PXR is a prominent receptor that is responsible for xenobiotic excretion and drug-drug interactions.
Joshi M. Ramanjulu +5 more
openaire +2 more sources
The pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, phase II enzymes, and multidrug efflux pumps. Therefore, PXR is a prominent receptor that is responsible for xenobiotic excretion and drug-drug interactions.
Joshi M. Ramanjulu +5 more
openaire +2 more sources
Tunicate pregnane X receptor (PXR) orthologs: Transcript characterization and natural variation
Marine Genomics, 2015Vertebrate pregnane X receptor (PXR, NR1I2), a ligand-activated nuclear receptor (NR), regulates expression of detoxification genes. Vertebrate PXR orthologs may adaptively evolve to bind deleterious/toxic xenobiotics typically encountered by organisms from their diet.
Ingrid, Richter, Andrew E, Fidler
openaire +2 more sources
Experimental Cell Research, 2022
The pregnane X receptor (PXR, NR1I2) belongs to the nuclear receptor family and functions as a xenobiotic and endobiotic sensor by binding to various molecules through its relatively flexible ligand-binding domain. In addition to these well-known canonical roles, we previously reported that PXR represses osteoblast differentiation.
Naoya Saeki +7 more
openaire +2 more sources
The pregnane X receptor (PXR, NR1I2) belongs to the nuclear receptor family and functions as a xenobiotic and endobiotic sensor by binding to various molecules through its relatively flexible ligand-binding domain. In addition to these well-known canonical roles, we previously reported that PXR represses osteoblast differentiation.
Naoya Saeki +7 more
openaire +2 more sources
Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR)
Toxicology and Applied Pharmacology, 2005The pregnane X receptor (PXR) mediates the induction of enzymes involved in steroid metabolism and xenobiotic detoxification. The receptor is expressed in liver and intestinal tissues and is activated by a wide range of compounds. The ability of a diverse range of dietary compounds to activate PXR-mediated transcription was assayed in HuH7 cells ...
Miriam N, Jacobs +2 more
openaire +2 more sources
Inflammatory Bowel Diseases, 2011
The pregnane X receptor (PXR/NR1I2) is an important regulator of xenobiotic metabolism and intestinal integrity. However, there are controversial studies on the role of PXR/NR1I2 in inflammatory bowel disease (IBD). We therefore initiated the largest analysis to date on PXR/NR1I2 gene variants in IBD patients.Genomic DNA from 2823 individuals of ...
Glas, J. +15 more
openaire +3 more sources
The pregnane X receptor (PXR/NR1I2) is an important regulator of xenobiotic metabolism and intestinal integrity. However, there are controversial studies on the role of PXR/NR1I2 in inflammatory bowel disease (IBD). We therefore initiated the largest analysis to date on PXR/NR1I2 gene variants in IBD patients.Genomic DNA from 2823 individuals of ...
Glas, J. +15 more
openaire +3 more sources
Drug Metabolism and Disposition, 2012
Human UDP-glucuronosyltransferase (UGT) 1A1 is a critical enzyme responsible for detoxification and metabolism of endogenous and exogenous lipophilic compounds such as bilirubin. The present study shows how cyclin-dependent kinase (CDK) inhibitor roscovitine stimulated the expression of UGT1A1 in HepG2 cells.
Junko, Sugatani +6 more
openaire +2 more sources
Human UDP-glucuronosyltransferase (UGT) 1A1 is a critical enzyme responsible for detoxification and metabolism of endogenous and exogenous lipophilic compounds such as bilirubin. The present study shows how cyclin-dependent kinase (CDK) inhibitor roscovitine stimulated the expression of UGT1A1 in HepG2 cells.
Junko, Sugatani +6 more
openaire +2 more sources
Allelic variation of the pregnane X receptor (PXR) and CYP3A4 activity
Clinical Pharmacology & Therapeutics, 2003Clinical Pharmacology & Therapeutics (2003) 73, P61–P61; doi:
A. Gaedigk +4 more
openaire +1 more source
Drug Metabolism and Disposition, 2008
The pregnane X receptor (PXR) is known as the xenosensing receptor responsible for coordinated regulation of metabolic genes in response to diverse xenobiotic challenges. In particular, the ability of the PXR to regulate CYP3A4, the enzyme capable of metabolizing more than 60% of all pharmaceuticals, defines its metabolic importance. Currently the list
Leslie M, Tompkins +2 more
openaire +2 more sources
The pregnane X receptor (PXR) is known as the xenosensing receptor responsible for coordinated regulation of metabolic genes in response to diverse xenobiotic challenges. In particular, the ability of the PXR to regulate CYP3A4, the enzyme capable of metabolizing more than 60% of all pharmaceuticals, defines its metabolic importance. Currently the list
Leslie M, Tompkins +2 more
openaire +2 more sources
Toxicology, 2009
Technical pentabrominated diphenyl ether (pentaBDE mix) is a mixture of polybrominated diphenyl ethers (PBDEs) which has been widely used as a flame retardant. Since its ban in several countries it has been replaced by other brominated flame retardants such as hexabromocyclododecane (HBCD).
Yvonne, Fery +4 more
openaire +2 more sources
Technical pentabrominated diphenyl ether (pentaBDE mix) is a mixture of polybrominated diphenyl ethers (PBDEs) which has been widely used as a flame retardant. Since its ban in several countries it has been replaced by other brominated flame retardants such as hexabromocyclododecane (HBCD).
Yvonne, Fery +4 more
openaire +2 more sources
Bioorganic & Medicinal Chemistry, 2018
Pregnane X receptor (PXR) is a ligand-dependent transcription factor that is considered to be a potential therapeutic target for multiple diseases. Herein, we report the development and structure-activity relationship studies of a new series of hPXR agonists.
Hirozumi, Toyama +4 more
openaire +2 more sources
Pregnane X receptor (PXR) is a ligand-dependent transcription factor that is considered to be a potential therapeutic target for multiple diseases. Herein, we report the development and structure-activity relationship studies of a new series of hPXR agonists.
Hirozumi, Toyama +4 more
openaire +2 more sources