Results 111 to 120 of about 30,346 (255)

Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands [PDF]

, 2019
The synaptic α1β2γ2 ...
Akk, Gustav, Burbridge, Ariel B, Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Steinbach, Joe Henry   +5 more
core   +1 more source

The major brain cholesterol metabolite 24(s)-hydroxycholesterol is a potent allosteric modulator of N-methyl-d-aspartate receptors [PDF]

, 2013
N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical to the regulation of excitatory synaptic function in the CNS.
Belfort, Gabriel M, Chow, Brian Y, Crawford, Devon C, Doherty, James J, Hammond, Rebecca S, Izumi, Yukitoshi, Linsenbardt, Andrew J, Mennerick, Steven J, Paul, Steven M, Robichaud, Albert J, Shu, Hong-Jin, Zorumski, Charles F   +11 more
core   +2 more sources

Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2012
AIM The present study was designed to investigate the activity of two glibenclamide derivatives on glucose concentration. An additional aim was to identify the biodistribution of glibenclamide derivatives in different organs in a diabetic animal model.
L. Figueroa-Valverde, F. Díaz-Cedillo, M. López-Ramos, E. García-Cervera, E. Pool-Gómez, Carlos Cardeña-Arredondo, Graciela Ancona-Leon   +6 more
semanticscholar   +1 more source

Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]

, 2016
NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E, Lopez, Melany N, Wilding, Timothy J   +2 more
core   +2 more sources

Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life

Neuropsychiatric Disease and Treatment, 2018
Chien-Yu Chen,1 Chih-Ching Wu,2,3 Yu-Chi Huang,1 Chi-Fa Hung,1 Liang-Jen Wang4 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2Molecular Medicine Research Center, Chang ...
Chen CY, Wu CC, Huang YC, Hung CF, Wang LJ   +4 more
doaj  

Norepinephrine stimulates progesterone production in highly estrogenic bovine granulosa cells cultured under serum-free, chemically defined conditions

Reproductive Biology and Endocrinology, 2012
Background Since noradrenergic innervation was described in the ovarian follicle, the actions of the intraovarian catecholaminergic system have been the focus of a variety of studies.
Piccinato Carla A, Montrezor Luis H, Collares Cristhianna AV, Vireque Alessandra A, Rosa e Silva Alzira AM   +4 more
doaj   +1 more source

GABAergic neuroactive steroids: a new frontier in bipolar disorders?

Behavioral and Brain Functions, 2012
Neurosteroids are synthesized in the brain and modulate brain excitability. There is increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their influence on mood.
Carta Mauro Giovanni, Bhat Krishna M, Preti Antonio   +2 more
doaj   +1 more source

A Regioselective Synthesis of E-Guggulsterone

Molecules, 2011
We have successfully prepared E-guggulsterone from 16,17-epoxy-pregnenolone in 84% yield over two steps via a hydrazine reduction and Oppenhauer oxidation.
Jungyeob Ham, Jungwook Chin, Heonjoong Kang   +2 more
doaj   +1 more source

How Steroids Steer T Cells

Cell Reports, 2014
Recent papers from Mahata et al. and Bereshchenko et al. reveal how steroids steer immune responses by tipping T helper (Th) subset balances and activities.
Claude Libert, Lien Dejager
doaj   +1 more source

Pregnenolone and progesterone production from natural sterols using recombinant strain of Mycolicibacterium smegmatis mc2 155 expressing mammalian steroidogenesis system

Microbial Cell Factories
Background Pregnenolone and progesterone are the life-important steroid hormones regulating essential vital functions in mammals, and widely used in different fields of medicine.
Mikhail Karpov, Nicolai Strizhov, Ludmila Novikova, Tatyana Lobastova, Sergey Khomutov, Andrei Shutov, Alexey Kazantsev, Marina Donova   +7 more
doaj   +1 more source