Results 91 to 100 of about 44,045 (236)
Initial V‐A ECMO Flow‐Index and Its Association With Inflammation, Organ Failure, and Outcomes
Artificial Organs, EarlyView.Higher initial V‐A ECMO flow‐index was associated with greater shock severity and independently associated with multi‐organ failure. Early hemolysis may partly contribute to this association, particularly in eCPR patients, whereas no significant indirect effect through IL‐6 was observed.
Kostiantyn Kozakov +9 more
wiley +1 more source
Shaping Future Children, Sex Selection, and “Normal” Human Capacities
Bioethics, EarlyView.ABSTRACT If we think that parents have an obligation to have a healthy child then we need to know what counts as healthy, when male and female children are born with very different capacities. If we give up on the idea that our obligations to use technologies of genetic selection are discharged once we try to secure the birth of a healthy child, as ...
Robert Sparrow
wiley +1 more source
Indications for Preimplantation Genetic Testing for Aneuploidy (PGT-A).
, 2018 Indications for Preimplantation Genetic Testing for Aneuploidy (PGT-A).
Rupali Chopra (246435) +7 more
core +1 more source
Derivation of Mouse Dome‐Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts
Cell Proliferation, EarlyView.Here, Liu et al. report the generation of mouse dome‐shaped trophoblast stem cells (dTSCs) with low heterogeneity and autonomous differentiation potential. dTSCs robustly generate all trophoblast lineages in vitro and contribute to the placenta in vivo, providing a refined model for studying trophoblast development and related disorders.
Minli Liu +8 more
wiley +1 more source
Technology to the rescue: how to uncover the role of transposable elements in preimplantation development [PDF]
Transposable elements (TEs) are highly expressed in preimplantation development. Preimplantation development is the phase when the cells of the early embryo undergo the first cell fate choice and change from being totipotent to pluripotent.
core +1 more source
RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms
The FEBS Journal, EarlyView.RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon +4 more
wiley +1 more source
The embryo as moral work object: PGD/IVF staff views and experiences [PDF]
, 2008 Copyright @ 2008 the authors. This article is available in accordance with the Creative Commons Deed, Attribution 2.5, see http://creativecommons.org/licenses/by-nc-nd/2.5/deed.en_CA.We report on one aspect of a study that explored the views and ...
Williams, C +5 more
core +1 more source
Gender, Work &Organization, EarlyView.ABSTRACT Managing the work‐fertility interface is a major challenge for organizations when implementing fertility policies. These policies cover a broad spectrum of areas including clinical treatments, preservation and storage of eggs and sperm, preimplantation and diagnostics, and non‐clinical family‐building assistance. They also differ from standard
Clíodhna MacKenzie +2 more
wiley +1 more source
Next generation sequencing for preimplantation genetic testing of blastocysts aneuploidies in women of different ages [PDF]
, 2015 Most of the current preimplantation genetic screening of aneuploidies tests are based on the low quality and low density comparative genomic hybridization arrays. The results are based on fewer than 2,700 probes.
Krzysztof Lukaszuk +15 more
core +2 more sources
, 1981 NUCLEAR TRANSPLANTATION IN MUS MUSCULUS: DEVELOPMENTAL POTENTIAL OF NUCLEI FROM PREIMPLANTATION EMBRYOS Nuclear Transplantation in Mus musculus: Developmental Potential of Nuclei from Preimplantation Embryos (23) (-
Illmensee, Karl Peter C. Hoppe
core +1 more source