Results 91 to 100 of about 2,389 (154)
Sci‐Fi Parenthood and the End of Love
Journal of Social Philosophy, EarlyView.
Daniela Cutas
wiley +1 more source
Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3
Mitofusin 1 (MFN1) plays a crucial role in mitochondrial fusion and oocyte development. However, its function in preimplantation embryonic development and its potential involvement in epigenetic regulation remain poorly understood.
Xiao‐yan Shi +9 more
doaj +1 more source
ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi +5 more
wiley +1 more source
This study chronicles all described subspecies of snow sheep (Ovis nivicola) since 1829, reviewing taxonomic assessments by key systematists. Using genome‐wide SNP genotyping on 337 samples from 15 populations, we validate and refine subspecies classifications, revealing eight genetic clusters and proposing a new subspecies (O. n. ernsti).
Arsen V. Dotsev +25 more
wiley +1 more source
Environmental toxicants may disrupt developmental pathways via strong molecular docking interactions with hub FGF proteins (FGF9 and FGF4) like dibenzo‐p‐dioxin (−7.2 kcal/mol) at the ASN146 residue of FGF9, driving congenital malformations as revealed by PPI networks and toxicity profiling.
Adarsh Kumar Shukla +3 more
wiley +1 more source
Pregnancy in diabetic females causes delay in early stages of embryonic growth and development and higher incidence of congenital malformations and spontaneous miscarriage compared with those of non-diabetic conditions.
Iraj Amiri +4 more
doaj
Abstract Germline pathogenic variants in the RUNX1 gene lead to the condition RUNX1‐familial platelet disorder (RUNX1‐FPD). This condition is associated with a 30%–50% lifetime risk of hematologic malignancies, including acute myeloid leukemia. In addition to physical manifestations including prolonged bleeding and easy bruising, individuals with RUNX1‐
Olivia Kearns +5 more
wiley +1 more source
The Recommendation Paradox: Perspectives on Genetic Testing in Huntington's Disease Families
ABSTRACT Huntington's disease (HD) families face complex decisions about predictive genetic testing and reproductive options, including preimplantation genetic testing (PGT), and particularly PGT for Monogenic Disorders (PGT‐M). We examined attitudes toward genetic testing and reproductive options across affected groups within HD families (e.g., people
Noit Inbar +7 more
wiley +1 more source
Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley +1 more source
ABSTRACT While molecular signature contributes to sperm quality and fertility potential, sperm may lost key molecules during cryopreservation. Since sperm cells are transcriptionally inert and rely on interactions with epididymosomes (epEVs) to acquire molecules, herein, we investigated the effects of the addition of epEVs to the cryopreservation ...
Laura Gabrielli Haupenthal +9 more
wiley +1 more source

