Results 91 to 100 of about 2,389 (154)

Sci‐Fi Parenthood and the End of Love

open access: yes
Journal of Social Philosophy, EarlyView.
Daniela Cutas
wiley   +1 more source

Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3

open access: yesAdvanced Science
Mitofusin 1 (MFN1) plays a crucial role in mitochondrial fusion and oocyte development. However, its function in preimplantation embryonic development and its potential involvement in epigenetic regulation remain poorly understood.
Xiao‐yan Shi   +9 more
doaj   +1 more source

Unveiling New Insights: Reinterpreting DES Mutation, p.Arg383His, Through a Study of an Iranian Family With Isolated Hypertrophic Cardiomyopathy, Implication for Phenotype–Genotype Correlation Analysis

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi   +5 more
wiley   +1 more source

Unraveling the Evolutionary History of Snow Sheep (Ovis nivicola): Genome‐Wide Single Nucleotide Polymorphism Analysis Reveals Genetic Diversity and Clarifies Taxonomy

open access: yesEcology and Evolution, Volume 16, Issue 8, August 2026.
This study chronicles all described subspecies of snow sheep (Ovis nivicola) since 1829, reviewing taxonomic assessments by key systematists. Using genome‐wide SNP genotyping on 337 samples from 15 populations, we validate and refine subspecies classifications, revealing eight genetic clusters and proposing a new subspecies (O. n. ernsti).
Arsen V. Dotsev   +25 more
wiley   +1 more source

A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Environmental toxicants may disrupt developmental pathways via strong molecular docking interactions with hub FGF proteins (FGF9 and FGF4) like dibenzo‐p‐dioxin (−7.2 kcal/mol) at the ASN146 residue of FGF9, driving congenital malformations as revealed by PPI networks and toxicity profiling.
Adarsh Kumar Shukla   +3 more
wiley   +1 more source

The Study of Nitric Oxide Effects in Control of Mouse Preimplantation Embryonic Defects in High Glucosis Media

open access: yesپزشکی بالینی ابن سینا, 2003
Pregnancy in diabetic females causes delay in early stages of    embryonic growth and development and higher incidence of congenital malformations and spontaneous miscarriage compared with those of non-diabetic conditions.
Iraj Amiri   +4 more
doaj  

Psychosocial aspects of RUNX1‐familial platelet disorder in adolescents and young adults: “The fear of knowing it could happen sometime down the road”

open access: yesJournal of Genetic Counseling, Volume 35, Issue 4, August 2026.
Abstract Germline pathogenic variants in the RUNX1 gene lead to the condition RUNX1‐familial platelet disorder (RUNX1‐FPD). This condition is associated with a 30%–50% lifetime risk of hematologic malignancies, including acute myeloid leukemia. In addition to physical manifestations including prolonged bleeding and easy bruising, individuals with RUNX1‐
Olivia Kearns   +5 more
wiley   +1 more source

The Recommendation Paradox: Perspectives on Genetic Testing in Huntington's Disease Families

open access: yesJournal of Genetic Counseling, Volume 35, Issue 4, August 2026.
ABSTRACT Huntington's disease (HD) families face complex decisions about predictive genetic testing and reproductive options, including preimplantation genetic testing (PGT), and particularly PGT for Monogenic Disorders (PGT‐M). We examined attitudes toward genetic testing and reproductive options across affected groups within HD families (e.g., people
Noit Inbar   +7 more
wiley   +1 more source

Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy

open access: yesMolecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley   +1 more source

Epididymosome‐Supplemented Extender Induces Changes in Morpho‐Functional Traits and microRNA Levels of Post‐Thaw Sperm and Improves Embryo Developmental Potential

open access: yesMolecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT While molecular signature contributes to sperm quality and fertility potential, sperm may lost key molecules during cryopreservation. Since sperm cells are transcriptionally inert and rely on interactions with epididymosomes (epEVs) to acquire molecules, herein, we investigated the effects of the addition of epEVs to the cryopreservation ...
Laura Gabrielli Haupenthal   +9 more
wiley   +1 more source

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