Results 71 to 80 of about 44,045 (236)

Uji Ekstrak Etanol Daun Pegagan (Centella asiatica L. Urban) terhadap Fertilitas Tikus Putih (Rattus norvegicus L.) Betina pada Tahap Praimplantasi

Al-Kauniyah Jurnal Biologi, 2015
This study aims to test extract ethanol of leaves Pennywort (Centellaasiatica L. Urban) toward fertilitation of female white mice Sprague Dawley strain at the praimplantation.
Yassir Dzulfiqor, Budhi Akbar, Susilo Susilo   +2 more
doaj   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice

Advanced Science
Epigenetic modifiers that accumulate in oocytes, play a crucial role in steering the developmental program of cleavage embryos and initiating life. However, the identification of key maternal epigenetic regulators remains elusive.
Qing Tian, Ying Yin, Yu Tian, Yufan Wang, Yong‐feng Wang, Rikiro Fukunaga, Toshihiro Fujii, Ai‐hua Liao, Lei Li, Wei Zhang, Ximiao He, Wenpei Xiang, Li‐quan Zhou   +12 more
doaj   +1 more source

Preimplantation diagnosis for immunodeficiencies

Reproductive BioMedicine Online, 2007
Preimplantation genetic diagnosis (PGD) has become an established procedure for the detection of single gene disorders, and has recently been performed together with human leukocyte antigen (HLA) typing for couples with children affected by genetic disorders that require HLA-identical stem cell transplantation therapy. For these couples, PGD can ensure
Yury, Verlinsky, Svetlana, Rechitsky, Tatyana, Sharapova, Katya, Laziuk, Irina, Barsky, Oleg, Verlinsky, Ilan, Tur-Kaspa, Anver, Kuliev   +7 more
openaire   +2 more sources

ATXN8OS Intermediate Expansion Acts as a Genetic Modifier in Spinocerebellar Ataxia Type 48 (SCA48/STUB1)

Movement Disorders, EarlyView.
Abstract Background Association between monoallelic STUB1 variant and expanded ATXN8OS alleles was recently reported, suggesting a pathogenic interaction that may influence spinocerebellar ataxia type 48 (SCA48) phenotype. Objectives We investigated the frequency and clinical impact of ATXN8OS in a large cohort of STUB1 carriers compared to individuals
Charlotte Mouraux, Jean‐Loup Méreaux, Claire‐Sophie Davoine, Léna Guillot Noel, Emilien Petit, Quentin Thomas, Adem Nasraoui, Anna Heinzmann, Claire Ewenczyk, Alexis Brice, Alexandra Durr, Giulia Coarelli   +11 more
wiley   +1 more source

MUC1 Protects Preimplantation Embryos In Vitro via Clearance of ROS by Triggering Mitophagy

Cells
Embryos being treated using assisted reproductive technology (ART) are unavoidably exposed to physical stressors, thus producing reactive oxygen species (ROS) which trigger mitophagy to support embryonic development.
Jingping Yang, Danjun Li, Chihyu Yang, Huayun Deng, Kaibo Lin, Bing Liao, Xiaodong Liao, Yue Liu, Qifeng Lyu, Lei Huang   +9 more
doaj   +1 more source

Dynamic Alternative Splicing During Mouse Preimplantation Embryo Development

Frontiers in Bioengineering and Biotechnology, 2020
The mechanism of alternative pre-mRNA splicing (AS) during preimplantation development is largely unknown. In order to capture the dynamic changes of AS occurring during embryogenesis, we carried out bioinformatics analysis based on scRNA-seq data over ...
Yongqiang Xing, Yongqiang Xing, Wuritu Yang, Guoqing Liu, Guoqing Liu, Xiangjun Cui, Xiangjun Cui, Hu Meng, Hu Meng, Hongyu Zhao, Hongyu Zhao, Xiujuan Zhao, Xiujuan Zhao, Jun Li, Jun Li, Zhe Liu, Michael Q. Zhang, Lu Cai, Lu Cai   +18 more
doaj   +1 more source

Evaluating Autophagy in Preimplantation Embryos

Autophagy Reports, 2022
Autophagy is an essential cellular degradation pathway in the mammalian preimplantation embryo. In this review, the process of autophagy is outlined and its function pertaining to preimplantation embryos is discussed.
Zuleika C. L. Leung, Hailey L. M. Hunter, Basim Abu Rafea, Andrew J. Watson, Dean H. Betts   +4 more
doaj   +1 more source

Preimplantation Genetic Diagnosis

AMA Journal of Ethics, 2001
Preimplantation genetic diagnosis raises ethical and moral concerns about using one person as a means to save another, especially as highlighted in recent cases where parents have more children in the hopes of saving a sick child. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +2 more sources

Preimplantation genetic screens [PDF]

Science, 2015
Although our knowledge of genetic abnormalities that cause health disorders is expanding, the pace of discovering cures for genetic diseases is not nearly as fast. However, technologies applicable to preventing heritable genetic diseases have been developing, among them so-called “next-generation sequencing.” This efficient and inexpensive means to ...
openaire   +2 more sources