Results 31 to 40 of about 214,960 (327)

Functional relevance of miRNAs in premature ageing [PDF]

open access: yesMechanisms of Ageing and Development, 2017
Ageing is a complex biological process characterized by the progressive loss of biological fitness due to the accumulation of macromolecular and cellular damage that affects most living organisms. Moreover, ageing is an important risk factor for many pathologies, including cardiovascular diseases, neurological disorders, and cancer. However, the ageing
Caravia, Xurde M.   +3 more
openaire   +4 more sources

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS [PDF]

open access: yes, 2018
Defects in stress response are main determinants of cellular senescence and organism aging. In fibroblasts from patients affected by Hutchinson-Gilford progeria, a severe LMNA-linked syndrome associated with bone resorption, cardiovascular disorders, and
Andrenacci, Davide   +13 more
core   +2 more sources

Premature and accelerated aging: HIV or HAART? [PDF]

open access: yesFrontiers in Genetics, 2013
Highly active antiretroviral therapy (HAART) has significantly increased life expectancy of the human immunodeficiency virus (HIV)-positive population. Nevertheless, the average lifespan of HIV-patients remains shorter compared to uninfected individuals.
Smith, R.L.   +4 more
openaire   +6 more sources

Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development [PDF]

open access: yes, 2013
Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes ...
Hashizume Osamu   +11 more
core   +1 more source

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise [PDF]

open access: yes, 2011
The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy ...
Darzynkiewicz, Zbigniew   +3 more
core   +1 more source

Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review

open access: yesCells, 2021
Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic causative factors of aging. Intrinsic aging is related to compromised cellular proliferative capacity, and may be accelerated by harmful environmental ...
Angelika Bielach-Bazyluk   +6 more
doaj   +1 more source

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations [PDF]

open access: yes, 2016
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death.
Benítez Iglesias, Raúl   +14 more
core   +2 more sources

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

open access: yesNature Communications, 2018
Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related ...
Gabriel Balmus   +17 more
doaj   +1 more source

NF-κB in premature aging

open access: yesAging, 2012
During decades, aging has been regarded as the consequence of a stochastic process caused by the accumulative effect of damaged molecules. However, recent experimental evidences have extended this view and suggested that aging also requires active signaling programs for the maintenance of the aged state [1].
Carlos López-Otín   +2 more
openaire   +3 more sources

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