Results 161 to 170 of about 26,399 (217)

Functional Characterization of a Signal Peptide Peptidase in <i>Phaffia rhodozyma</i> Reveals a Potential Role in Protein Stress Response but Not in Activation of the SREBP Ortholog Sre1. [PDF]

Int J Mol Sci
Baeza M, Gómez M, Apariz G, Barahona S, Alcaíno J.   +4 more
europepmc   +1 more source

Correction to: Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes. [PDF]

J Neuropathol Exp Neurol
europepmc   +1 more source

Expression, Reinigung und biophysikalische Charakterisierung von humanen Presenilin 2

, 2013
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Increased Expression of Presenilin 2 Inhibits Protein Synthesis

Molecular and Cellular Neuroscience, 2002
Mutations in the presenilin genes PS1 and PS2 are a major cause of early onset familial Alzheimer's disease (AD). Previous studies have suggested that presenilins have several functions, including gamma-secretase activity. It was also shown that presenilin expression is increased in the brains of some AD patients and ischemic rodents. The present study
Amir, Gamliel, Carmit, Teicher, Daniel M, Michaelson, Laurent, Pradier, Tobias, Hartmann, Konrad, Beyreuther, Reuven, Stein   +6 more
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Cloning of the cDNA encoding rat presenilin-2

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
We report here the cDNA sequence of rat homologue of presenilin-2 (PS-2). The rat PS-2 cDNA encoded 448 amino acids, and the deduced amino acid sequence was highly homologous to those of the human (94.9%), mouse (96.4%) and Xenopus (70.8%). A minor splicing variant lacking a single glutamate was detected, while the product corresponding to the exon 9 ...
H, Tanahashi, T, Tabira
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Atypical dementia associated with a novel presenilin‐2 mutation

Annals of Neurology, 2003
Abstract We describe an Italian pedigree with hereditary dementia associated with a novel T122R mutation in the presenilin‐2 gene (PSEN2) . The clinical history, symptom presentation, and structural neuroimaging were consistent with an atypical form of dementia.
BINETTI G, SIGNORINI S, SQUITTI R, ALBERICI A, BENUSSI L, CASSETTA E, FRISONI GB, BARBIERO L, FEUDATARI E, NICOSIA F, TESTA C, ZANETTI O, GENNARELLI, Massimo, PERANI D, ANCHISI D, GHIDONI R, ROSSINI P.M.   +16 more
openaire   +6 more sources