Results 91 to 100 of about 25,523 (241)
Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology
Frontiers in Physiology, 2017 Mitochondrial dysfunction plays a pivotal role in the progression of Alzheimer's disease (AD), and yet the mechanisms underlying the impairment of mitochondrial function in AD remain elusive.
Sabrina Contino +11 more
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Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.ABSTRACT Extracellular vesicles (EVs) released from tissues can be found in human biofluids. EVs reflect the phenotypic state of their cell of origin, carrying informative molecular biomarkers within and between tissues, and represent a promising target for liquid biopsy.
Biancamaria Pierri +5 more
wiley +1 more source
Presenilin‐1 and intracellular calcium stores regulate neuronal glutamate uptake [PDF]
, 2004 Yaxiong Yang +4 more
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Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells
Journal of Lipid Research, 2004 Presenilin-1 (PS1) is an important determinant of the γ-secretase activity necessary for the generation of β-amyloid (Aβ), likely the central pathogenic molecule in Alzheimer's disease.
Yanzhu Liu +5 more
doaj +1 more source
Progress in RNA‐Targeted Therapeutics for Human Diseases
MedComm, Volume 7, Issue 2, February 2026.RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response [PDF]
, 1999 Maho Niwa +3 more
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Aging Cell, Volume 25, Issue 2, February 2026.Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang +11 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 4, Page 1646-1681, 15 February 2026.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Molecular cell biology of presenilins.
Folia Pharmacologica Japonica, 1999 Alzheimer's disease (AD), the most common cause of dementia in the elderly, is a progressive neurodegenerative disorder characterized pathologically by the presence of senile plaques and neurofibrillary tangles in the brains of affected individuals.
T, Tomita, T, Iwatsubo
openaire +3 more sources
Chromosome Missegregation and Trisomy 21 Mosaicism in Alzheimer's Disease
Neurobiology of Disease, 1999 A connection between Alzheimer's disease (AD) and Down syndrome (trisomy 21) is indicated by the fact that all Down syndrome individuals develop Alzheimer's disease neuropathology by the 4th decade of life. Previous studies have examined the frequency of
Lisa N. Geller, Huntington Potter
doaj +1 more source