Results 81 to 90 of about 25,523 (241)

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease‐associated genes in the Hispanic population

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is the most common form of dementia. Studies have suggested prevalence is greater in individuals self‐identifying as Hispanic. Population‐specific results enable personalized and equitable interventions. Ethnicity as a stratifier co‐occurs with genomic inflation due to heterogeneity.
Julian Daniel Sunday Willett, Mohamad Waqas, Serhiy Naumenko, Kristina Mullin, Julian Hecker, Lars Bertram, Christoph Lange, Ioannis Vlachos, Winston Hide, Rudolph E. Tanzi, Dmitry Prokopenko   +10 more
wiley   +1 more source

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source

Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling

Neurobiology of Disease, 2001
Mutations in presenilin-1 (PS1), the leading cause of early-onset, autosomal-dominant familial Alzheimer's disease (FAD), enhance calcium signaling mediated by inositol 1,4,5-trisphosphate (IP3).
Malcolm A. Leissring, Frank M. LaFerla, Nick Callamaras, Ian Parker   +3 more
doaj   +1 more source

Ethnic‐specific effects of the LILRB2–LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Genome‐wide association studies have identified numerous Alzheimer's disease (AD) susceptibility loci in European populations. However, the genetic architecture of AD in non‐European populations remains underinvestigated. METHODS We performed a genetic association study in East Asians (N = 8514) to validate known AD loci and ...
Han Cao, Ziyu Zheng, Xiaopu Zhou, Masataka Kikuchi, Hiu Yi Wong, Elaine Y. L. Cheng, Bonnie W. Y. Wong, Ronnie M. N. Lo, Maryam Shoai, Joyce R. Chong, Andrew L. T. Chan, Christopher Chen, Linda C. W. Lam, Vincent C. T. Mok, Timothy C. Y. Kwok, Japanese Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Neuroimaging Initiative, Yu Chen, Fanny C. F. Ip, Kin Y. Mok, Akinori Miyashita, Takeshi Ikeuchi, John Hardy, Amy K. Y. Fu, Nancy Y. Ip   +24 more
wiley   +1 more source

Toward the structure of presenilin/γ-secretase and presenilin homologs

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Presenilin is the catalytic component of the γ-secretase complex, a membrane-embedded aspartyl protease that plays a central role in biology and in the pathogenesis of Alzheimer's disease. Upon assembly with its three protein cofactors (nicastrin, Aph-1 and Pen-2), presenilin undergoes autoproteolysis into two subunits, each of which contributes one of
openaire   +2 more sources

Presenilin Promotes Dietary Copper Uptake

PLoS ONE, 2013
Dietary copper is essential for multicellular organisms. Copper is redox active and required as a cofactor for enzymes such as the antioxidant Superoxide Dismutase 1 (SOD1). Copper dyshomeostasis has been implicated in Alzheimer's disease. Mutations in the presenilin genes encoding PS1 and PS2 are major causes of early-onset familial Alzheimer's ...
Southon, A, Greenough, MA, Ganio, G, Bush, AI, Burke, R, Camakaris, J   +5 more
openaire   +5 more sources

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans

Antioxidants, 2018
Neurodegenerative diseases like Alzheimer’s disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies.
Shaarika Sarasija, Kenneth R. Norman
doaj   +1 more source

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source

Presenilins [PDF]

Current Biology, 2001
Brou, Christel, Israël, Alain
openaire   +1 more source