It’s lights out for presynaptic terminals [PDF]
Neuron, 2021 Reliable optogenetic tools for sustained, projection-specific presynaptic silencing have been elusive. Recently in Neuron, Mahn et al. (2021) and Copits et al. (2021) describe how the light-activated inhibitory GPCRs eOPN3 and PPO can be used to reversibly suppress synaptic transmission in mice.
Xinyi Jenny He, Matthew R. Banghart
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Neurexin mediates the assembly of presynaptic terminals [PDF]
Nature Neuroscience, 2003 Neurexins are a large family of proteins that act as neuronal cell-surface receptors. The function and localization of the various neurexins, however, have not yet been clarified. Beta-neurexins are candidate receptors for neuroligin-1, a postsynaptic membrane protein that can trigger synapse formation at axon contacts.
Camin Dean +6 more
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Single Calcium Channel Nanodomains Drive Presynaptic Calcium Entry at Lamprey Reticulospinal Presynaptic Terminals. [PDF]
J Neurosci, 2022 Efficient and reliable neurotransmission requires precise coupling between action potentials (APs), Ca 2+ entry and neurotransmitter release. However, Ca 2+ requirements for release, including the number of channels required, their subtypes, and their ...
Ramachandran S +3 more
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Correction: Central Presynaptic Terminals Are Enriched in ATP but the Majority Lack Mitochondria. [PDF]
PLoS One, 2017 Chavan V +7 more
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Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals. [PDF]
Exp Mol Med, 2021 AbstractNeddylation is a posttranslational modification in which NEDD8 is conjugated to a target substrate by cellular processes similar to those involved in ubiquitination. Recent studies have identified PSD-95 and cofilin as substrates for neddylation in the brain and have shown that neddylation modulates the maturation and stability of dendritic ...
Kang M +6 more
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The Molecular Architecture of Ribbon Presynaptic Terminals [PDF]
Molecular Neurobiology, 2009 The primary receptor neurons of the auditory, vestibular, and visual systems encode a broad range of sensory information by modulating the tonic release of the neurotransmitter glutamate in response to graded changes in membrane potential. The output synapses of these neurons are marked by structures called synaptic ribbons, which tether a pool of ...
George Zanazzi, Gary Matthews
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Investigate Synaptic Vesicles Mobility in Neuronal Culture Axons by FRAP Imaging
Bio-Protocol, 2021 Synaptic vesicles (SVs) are clustered in the presynaptic terminals and consistently trafficking along axons. Based on their release features, SVs are classified into different “pools”.
Xiao Min Zhang +2 more
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Developmental up-regulation of vesicular glutamate transporter-1 promotes neocortical presynaptic terminal development. [PDF]
PLoS ONE, 2012 Presynaptic terminal formation is a complex process that requires assembly of proteins responsible for synaptic transmission at sites of axo-dendritic contact.
Corbett T Berry +3 more
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Neurexin nanoclusters: A novel structure at presynaptic terminals. [PDF]
J Cell Biol, 2019 The trans-synaptic cell adhesion molecule neurexin regulates synaptic functions but its high-resolution subcellular localization and dynamics were unknown. Trotter et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201812076) describe previously unrecognized nanoscale clusters of neurexin-1 in presynaptic terminals and their regulation by ADAM10 ...
Kawaguchi D, Gotoh Y.
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Excitement about Inhibitory Presynaptic Terminals [PDF]
Neuron, 2015 Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (2015) show that at Purkinje cell ...
David H.F. Vandael +2 more
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